Defective dystrophic thymus determines degenerative changes in skeletal muscle

Immune cells are known to aggravate the inflammatory impact of Duchene muscular dystrophy. Here, the authors describe impaired thymic development and suggest thymic involution in this model of disease is linked to disease acceleration due to impaired immunological tolerance.

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Autores principales:	Andrea Farini, Clementina Sitzia, Chiara Villa, Barbara Cassani, Luana Tripodi, Mariella Legato, Marzia Belicchi, Pamela Bella, Caterina Lonati, Stefano Gatti, Massimiliano Cerletti, Yvan Torrente
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d8c793c26284821978e4d5c5eaaacf0
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spelling	oai:doaj.org-article:1d8c793c26284821978e4d5c5eaaacf02021-12-02T14:21:10ZDefective dystrophic thymus determines degenerative changes in skeletal muscle10.1038/s41467-021-22305-x2041-1723https://doaj.org/article/1d8c793c26284821978e4d5c5eaaacf02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22305-xhttps://doaj.org/toc/2041-1723Immune cells are known to aggravate the inflammatory impact of Duchene muscular dystrophy. Here, the authors describe impaired thymic development and suggest thymic involution in this model of disease is linked to disease acceleration due to impaired immunological tolerance.Andrea FariniClementina SitziaChiara VillaBarbara CassaniLuana TripodiMariella LegatoMarzia BelicchiPamela BellaCaterina LonatiStefano GattiMassimiliano CerlettiYvan TorrenteNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea Farini Clementina Sitzia Chiara Villa Barbara Cassani Luana Tripodi Mariella Legato Marzia Belicchi Pamela Bella Caterina Lonati Stefano Gatti Massimiliano Cerletti Yvan Torrente Defective dystrophic thymus determines degenerative changes in skeletal muscle
description	Immune cells are known to aggravate the inflammatory impact of Duchene muscular dystrophy. Here, the authors describe impaired thymic development and suggest thymic involution in this model of disease is linked to disease acceleration due to impaired immunological tolerance.
format	article
author	Andrea Farini Clementina Sitzia Chiara Villa Barbara Cassani Luana Tripodi Mariella Legato Marzia Belicchi Pamela Bella Caterina Lonati Stefano Gatti Massimiliano Cerletti Yvan Torrente
author_facet	Andrea Farini Clementina Sitzia Chiara Villa Barbara Cassani Luana Tripodi Mariella Legato Marzia Belicchi Pamela Bella Caterina Lonati Stefano Gatti Massimiliano Cerletti Yvan Torrente
author_sort	Andrea Farini
title	Defective dystrophic thymus determines degenerative changes in skeletal muscle
title_short	Defective dystrophic thymus determines degenerative changes in skeletal muscle
title_full	Defective dystrophic thymus determines degenerative changes in skeletal muscle
title_fullStr	Defective dystrophic thymus determines degenerative changes in skeletal muscle
title_full_unstemmed	Defective dystrophic thymus determines degenerative changes in skeletal muscle
title_sort	defective dystrophic thymus determines degenerative changes in skeletal muscle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d8c793c26284821978e4d5c5eaaacf0
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Defective dystrophic thymus determines degenerative changes in skeletal muscle

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