EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy

Xupeng Mu,1 Fuqiang Zhang,1 Chenfei Kong,1 Hongmei Zhang,1 Wenjing Zhang,1 Rui Ge,2 Yi Liu,2 Jinlan Jiang1 1Department of Central Laboratory, China-Japan Union Hospital, 2State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, Chin...

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Autores principales:	Mu X, Zhang F, Kong C, Zhang H, Zhang W, Ge R, Liu Y, Jiang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Fe3O4 nanoparticles polydopamine chemo-photothermal therapy multifunctional nanocomposites Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1d8dbd736ae94adeadb885fe64c2c53d
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spelling	oai:doaj.org-article:1d8dbd736ae94adeadb885fe64c2c53d2021-12-02T01:01:58ZEGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy1178-2013https://doaj.org/article/1d8dbd736ae94adeadb885fe64c2c53d2017-04-01T00:00:00Zhttps://www.dovepress.com/egfr-targeted-delivery-of-dox-loaded-fe3o4polydopamine-multifunctional-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xupeng Mu,1 Fuqiang Zhang,1 Chenfei Kong,1 Hongmei Zhang,1 Wenjing Zhang,1 Rui Ge,2 Yi Liu,2 Jinlan Jiang1 1Department of Central Laboratory, China-Japan Union Hospital, 2State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China Abstract: Multifunctional nanocomposites that have multiple therapeutic functions together with real-time imaging capabilities have attracted intensive concerns in the diagnosis and treatment of cancer. This study developed epidermal growth factor receptor (EGFR) antibody-directed polydopamine-coated Fe3O4 nanoparticles (Fe3O4@PDA NPs) for magnetic resonance imaging and antitumor chemo-photothermal therapy. The synthesized Fe3O4@PDA-PEG-EGFR-DOX NPs revealed high storage capacity for doxorubicin (DOX) and high photothermal conversion efficiency. The cell viability assay of Fe3O4@PDA-PEG-EGFR NPs indicated that Fe3O4@PDA-PEG-EGFR NPs had no cell cytotoxicity. However, Fe3O4@PDA-PEG-EGFR-DOX NPs could significantly decrease cell viability (~5% of remaining cell viability) because of both photothermal ablation and near-infrared light-triggered DOX release. Meanwhile, the EGFR-targeted Fe3O4@PDA-PEG-EGFR-DOX NPs significantly inhibited the growth of tumors, showing a prominent in vivo synergistic antitumor effect. This study demonstrated the potential of using Fe3O4@PDA NPs for combined cancer chemo-photothermal therapy with increased efficacy. Keywords: Fe3O4 nanoparticles, polydopamine, chemo-photothermal therapy, multifunctional nanocomposites, DOXMu XZhang FKong CZhang HZhang WGe RLiu YJiang JDove Medical PressarticleFe3O4 nanoparticlespolydopaminechemo-photothermal therapymultifunctional nanocompositesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 2899-2911 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fe3O4 nanoparticles polydopamine chemo-photothermal therapy multifunctional nanocomposites Medicine (General) R5-920
spellingShingle	Fe3O4 nanoparticles polydopamine chemo-photothermal therapy multifunctional nanocomposites Medicine (General) R5-920 Mu X Zhang F Kong C Zhang H Zhang W Ge R Liu Y Jiang J EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
description	Xupeng Mu,1 Fuqiang Zhang,1 Chenfei Kong,1 Hongmei Zhang,1 Wenjing Zhang,1 Rui Ge,2 Yi Liu,2 Jinlan Jiang1 1Department of Central Laboratory, China-Japan Union Hospital, 2State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China Abstract: Multifunctional nanocomposites that have multiple therapeutic functions together with real-time imaging capabilities have attracted intensive concerns in the diagnosis and treatment of cancer. This study developed epidermal growth factor receptor (EGFR) antibody-directed polydopamine-coated Fe3O4 nanoparticles (Fe3O4@PDA NPs) for magnetic resonance imaging and antitumor chemo-photothermal therapy. The synthesized Fe3O4@PDA-PEG-EGFR-DOX NPs revealed high storage capacity for doxorubicin (DOX) and high photothermal conversion efficiency. The cell viability assay of Fe3O4@PDA-PEG-EGFR NPs indicated that Fe3O4@PDA-PEG-EGFR NPs had no cell cytotoxicity. However, Fe3O4@PDA-PEG-EGFR-DOX NPs could significantly decrease cell viability (~5% of remaining cell viability) because of both photothermal ablation and near-infrared light-triggered DOX release. Meanwhile, the EGFR-targeted Fe3O4@PDA-PEG-EGFR-DOX NPs significantly inhibited the growth of tumors, showing a prominent in vivo synergistic antitumor effect. This study demonstrated the potential of using Fe3O4@PDA NPs for combined cancer chemo-photothermal therapy with increased efficacy. Keywords: Fe3O4 nanoparticles, polydopamine, chemo-photothermal therapy, multifunctional nanocomposites, DOX
format	article
author	Mu X Zhang F Kong C Zhang H Zhang W Ge R Liu Y Jiang J
author_facet	Mu X Zhang F Kong C Zhang H Zhang W Ge R Liu Y Jiang J
author_sort	Mu X
title	EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
title_short	EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
title_full	EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
title_fullStr	EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
title_full_unstemmed	EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
title_sort	egfr-targeted delivery of dox-loaded fe3o4@polydopamine multifunctional nanocomposites for mri and antitumor chemo-photothermal therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1d8dbd736ae94adeadb885fe64c2c53d
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EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy

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