Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering

Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductiv...

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Autores principales:	Darlin Lantigua, Xinchen Wu, Sanika Suvarnapathaki, Michelle A. Nguyen, Gulden Camci-Unal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydrogels scaffolds bone photocrosslinking tissue engineering Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1d9256b6e6c445cdbc0603bc93324d29
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spelling	oai:doaj.org-article:1d9256b6e6c445cdbc0603bc93324d292021-11-25T16:46:31ZComposite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering10.3390/bioengineering81101692306-5354https://doaj.org/article/1d9256b6e6c445cdbc0603bc93324d292021-11-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/169https://doaj.org/toc/2306-5354Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductive microparticles have shown to be promising solutions in this field. In this study, gelatin methacrylate (GelMA) hydrogels containing bone meal powder (BP) particles were investigated for their osteoinductive capacity. As natural source of the bone mineral, we expect that BP improves the scaffold’s ability to induce mineralization. We characterized the physical properties of GelMA hydrogels containing various BP concentrations (0, 0.5, 5, and 50 mg/mL). The in vitro cellular studies revealed enhanced mechanical performance and the potential to promote the differentiation of pre-osteoblast cells. The in vivo studies demonstrated both promising biocompatibility and biodegradation properties. Overall, the biological and physical properties of this biomaterial is tunable based on BP concentration in GelMA scaffolds. The findings of this study offer a new composite scaffold for bone tissue engineering.Darlin LantiguaXinchen WuSanika SuvarnapathakiMichelle A. NguyenGulden Camci-UnalMDPI AGarticlehydrogelsscaffoldsbonephotocrosslinkingtissue engineeringTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 169, p 169 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogels scaffolds bone photocrosslinking tissue engineering Technology T Biology (General) QH301-705.5
spellingShingle	hydrogels scaffolds bone photocrosslinking tissue engineering Technology T Biology (General) QH301-705.5 Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
description	Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductive microparticles have shown to be promising solutions in this field. In this study, gelatin methacrylate (GelMA) hydrogels containing bone meal powder (BP) particles were investigated for their osteoinductive capacity. As natural source of the bone mineral, we expect that BP improves the scaffold’s ability to induce mineralization. We characterized the physical properties of GelMA hydrogels containing various BP concentrations (0, 0.5, 5, and 50 mg/mL). The in vitro cellular studies revealed enhanced mechanical performance and the potential to promote the differentiation of pre-osteoblast cells. The in vivo studies demonstrated both promising biocompatibility and biodegradation properties. Overall, the biological and physical properties of this biomaterial is tunable based on BP concentration in GelMA scaffolds. The findings of this study offer a new composite scaffold for bone tissue engineering.
format	article
author	Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal
author_facet	Darlin Lantigua Xinchen Wu Sanika Suvarnapathaki Michelle A. Nguyen Gulden Camci-Unal
author_sort	Darlin Lantigua
title	Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
title_short	Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
title_full	Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
title_fullStr	Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
title_full_unstemmed	Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
title_sort	composite scaffolds from gelatin and bone meal powder for tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1d9256b6e6c445cdbc0603bc93324d29
work_keys_str_mv	AT darlinlantigua compositescaffoldsfromgelatinandbonemealpowderfortissueengineering AT xinchenwu compositescaffoldsfromgelatinandbonemealpowderfortissueengineering AT sanikasuvarnapathaki compositescaffoldsfromgelatinandbonemealpowderfortissueengineering AT michelleanguyen compositescaffoldsfromgelatinandbonemealpowderfortissueengineering AT guldencamciunal compositescaffoldsfromgelatinandbonemealpowderfortissueengineering
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Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering

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