New understanding of electrical activity brought by surface potential of cardiomyocytes

Abstract Aiming at the problem encountered in the previous research: during the electrical activity of cardiomyocytes, the influent ions do not seem to be directly derived from the extracellular fluid. We chose to cut in from the colloidal properties of the cells, follow the basic principles of phys...

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Autores principales:	Ying Zhou, Yanfei Hao, Pei Sun, Guang Li, Mengqi Dong, Xuehui Fan, Xiuyun He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d942985b3094f30ae3087a88e967b52
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spelling	oai:doaj.org-article:1d942985b3094f30ae3087a88e967b522021-12-02T16:36:12ZNew understanding of electrical activity brought by surface potential of cardiomyocytes10.1038/s41598-021-86138-w2045-2322https://doaj.org/article/1d942985b3094f30ae3087a88e967b522021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86138-whttps://doaj.org/toc/2045-2322Abstract Aiming at the problem encountered in the previous research: during the electrical activity of cardiomyocytes, the influent ions do not seem to be directly derived from the extracellular fluid. We chose to cut in from the colloidal properties of the cells, follow the basic principles of physical chemistry, and establish hypotheses along the derivation of the structural characteristics of cardiomyocytes. Through the surface ion adsorption experiment and patch clamp experiment of living cells, under the condition of sequentially reducing the concentration of Na+ in the extracellular fluid, we observed the exchange and diffusion of adsorbed ions on the cell surface; the changes of inflow I Na, I Ca-L and action potential; and correlation between results. The results showed that the hypothesis is true. The observed parameter changes were consistent with the fact that during depolarization of cardiomyocytes, the ions of influx were derived from the inference of adsorbed ions on the cell surface; at the same time, it also provided an objective and realistic explanation for the generation of electrocardiogram.Ying ZhouYanfei HaoPei SunGuang LiMengqi DongXuehui FanXiuyun HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Zhou Yanfei Hao Pei Sun Guang Li Mengqi Dong Xuehui Fan Xiuyun He New understanding of electrical activity brought by surface potential of cardiomyocytes
description	Abstract Aiming at the problem encountered in the previous research: during the electrical activity of cardiomyocytes, the influent ions do not seem to be directly derived from the extracellular fluid. We chose to cut in from the colloidal properties of the cells, follow the basic principles of physical chemistry, and establish hypotheses along the derivation of the structural characteristics of cardiomyocytes. Through the surface ion adsorption experiment and patch clamp experiment of living cells, under the condition of sequentially reducing the concentration of Na+ in the extracellular fluid, we observed the exchange and diffusion of adsorbed ions on the cell surface; the changes of inflow I Na, I Ca-L and action potential; and correlation between results. The results showed that the hypothesis is true. The observed parameter changes were consistent with the fact that during depolarization of cardiomyocytes, the ions of influx were derived from the inference of adsorbed ions on the cell surface; at the same time, it also provided an objective and realistic explanation for the generation of electrocardiogram.
format	article
author	Ying Zhou Yanfei Hao Pei Sun Guang Li Mengqi Dong Xuehui Fan Xiuyun He
author_facet	Ying Zhou Yanfei Hao Pei Sun Guang Li Mengqi Dong Xuehui Fan Xiuyun He
author_sort	Ying Zhou
title	New understanding of electrical activity brought by surface potential of cardiomyocytes
title_short	New understanding of electrical activity brought by surface potential of cardiomyocytes
title_full	New understanding of electrical activity brought by surface potential of cardiomyocytes
title_fullStr	New understanding of electrical activity brought by surface potential of cardiomyocytes
title_full_unstemmed	New understanding of electrical activity brought by surface potential of cardiomyocytes
title_sort	new understanding of electrical activity brought by surface potential of cardiomyocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d942985b3094f30ae3087a88e967b52
work_keys_str_mv	AT yingzhou newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT yanfeihao newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT peisun newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT guangli newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT mengqidong newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT xuehuifan newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes AT xiuyunhe newunderstandingofelectricalactivitybroughtbysurfacepotentialofcardiomyocytes
_version_	1718383618825388032

New understanding of electrical activity brought by surface potential of cardiomyocytes

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