Terahertz refractive index-based morphological dilation for breast carcinoma delineation
Abstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1d97acfa14124386a66fcdf46c0d6ffa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1d97acfa14124386a66fcdf46c0d6ffa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1d97acfa14124386a66fcdf46c0d6ffa2021-12-02T13:18:01ZTerahertz refractive index-based morphological dilation for breast carcinoma delineation10.1038/s41598-021-85853-82045-2322https://doaj.org/article/1d97acfa14124386a66fcdf46c0d6ffa2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85853-8https://doaj.org/toc/2045-2322Abstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries.Quentin CassarSamuel CaraveraGaëtan MacGroganThomas BücherPhilipp HillgerUllrich PfeifferThomas ZimmerJean-Paul GuilletPatrick MounaixNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| description |
Abstract This paper reports investigations led on the combination of the refractive index and morphological dilation to enhance performances towards breast tumour margin delineation during conserving surgeries. The refractive index map of invasive ductal and lobular carcinomas were constructed from an inverse electromagnetic problem. Morphological dilation combined with refractive index thresholding was conducted to classify the tissue regions as malignant or benign. A histology routine was conducted to evaluate the performances of various dilation geometries associated with different thresholds. It was found that the combination of a wide structuring element and high refractive index was improving the correctness of tissue classification in comparison to other configurations or without dilation. The method reports a sensitivity of around 80% and a specificity of 82% for the best case. These results indicate that combining the fundamental optical properties of tissues denoted by their refractive index with morphological dilation may open routes to define supporting procedures during breast-conserving surgeries. |
| format |
article |
| author |
Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix |
| author_facet |
Quentin Cassar Samuel Caravera Gaëtan MacGrogan Thomas Bücher Philipp Hillger Ullrich Pfeiffer Thomas Zimmer Jean-Paul Guillet Patrick Mounaix |
| author_sort |
Quentin Cassar |
| title |
Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_short |
Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_full |
Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_fullStr |
Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_full_unstemmed |
Terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| title_sort |
terahertz refractive index-based morphological dilation for breast carcinoma delineation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1d97acfa14124386a66fcdf46c0d6ffa |
| work_keys_str_mv |
AT quentincassar terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT samuelcaravera terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT gaetanmacgrogan terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT thomasbucher terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT philipphillger terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT ullrichpfeiffer terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT thomaszimmer terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT jeanpaulguillet terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation AT patrickmounaix terahertzrefractiveindexbasedmorphologicaldilationforbreastcarcinomadelineation |
| _version_ |
1718393319887732736 |