A movable type bioelectronics printing technology for modular fabrication of biosensors

Abstract Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requ...

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Autores principales:	Muqun Yang, Mingyang Liu, Jing Cheng, Han Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d97c40f16c744499a04bb8b349c6843
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spelling	oai:doaj.org-article:1d97c40f16c744499a04bb8b349c68432021-11-21T12:23:52ZA movable type bioelectronics printing technology for modular fabrication of biosensors10.1038/s41598-021-01741-12045-2322https://doaj.org/article/1d97c40f16c744499a04bb8b349c68432021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01741-1https://doaj.org/toc/2045-2322Abstract Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requirement of cleanroom facility and limited fabrication materials, which significantly restrict the development and utilization of biosensors. Here, we propose a movable type bioelectronics printing method for the fabrication of biosensors by directly transferring bioelectronic materials onto various substrates using pre-fabricated molds. This simple, low-cost, yet robust method facilitates on-demand printing of master molds of partial or complete circuits on both rigid or flexible substrates. With this method, bioactive materials such as enzymes can be directly transferred onto substrates together with other electronic components, without complex modification after electrode fabrication using conventional methods. For demonstration, a dual-channel flexible electrochemical biosensor was fabricated by the movable type bioelectronics printing method for continuous monitoring of glucose and lactate. The movable type bioelectronics printing technology holds advantages of repeatability, flexibility and low cost for fabrication of biosensors on rigid and flexible substrates, as well as direct transfer printing of bioactive materials, which greatly promotes small-scale production of biosensors.Muqun YangMingyang LiuJing ChengHan WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muqun Yang Mingyang Liu Jing Cheng Han Wang A movable type bioelectronics printing technology for modular fabrication of biosensors
description	Abstract Biosensors have been widely used in various fields such as food industry, environmental testing and medical testing for their high sensitivity. However, current fabrication methods of biosensors, such as screen printing, micro fabrication and 3D printing suffer from complex procedures, requirement of cleanroom facility and limited fabrication materials, which significantly restrict the development and utilization of biosensors. Here, we propose a movable type bioelectronics printing method for the fabrication of biosensors by directly transferring bioelectronic materials onto various substrates using pre-fabricated molds. This simple, low-cost, yet robust method facilitates on-demand printing of master molds of partial or complete circuits on both rigid or flexible substrates. With this method, bioactive materials such as enzymes can be directly transferred onto substrates together with other electronic components, without complex modification after electrode fabrication using conventional methods. For demonstration, a dual-channel flexible electrochemical biosensor was fabricated by the movable type bioelectronics printing method for continuous monitoring of glucose and lactate. The movable type bioelectronics printing technology holds advantages of repeatability, flexibility and low cost for fabrication of biosensors on rigid and flexible substrates, as well as direct transfer printing of bioactive materials, which greatly promotes small-scale production of biosensors.
format	article
author	Muqun Yang Mingyang Liu Jing Cheng Han Wang
author_facet	Muqun Yang Mingyang Liu Jing Cheng Han Wang
author_sort	Muqun Yang
title	A movable type bioelectronics printing technology for modular fabrication of biosensors
title_short	A movable type bioelectronics printing technology for modular fabrication of biosensors
title_full	A movable type bioelectronics printing technology for modular fabrication of biosensors
title_fullStr	A movable type bioelectronics printing technology for modular fabrication of biosensors
title_full_unstemmed	A movable type bioelectronics printing technology for modular fabrication of biosensors
title_sort	movable type bioelectronics printing technology for modular fabrication of biosensors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d97c40f16c744499a04bb8b349c6843
work_keys_str_mv	AT muqunyang amovabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT mingyangliu amovabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT jingcheng amovabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT hanwang amovabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT muqunyang movabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT mingyangliu movabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT jingcheng movabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors AT hanwang movabletypebioelectronicsprintingtechnologyformodularfabricationofbiosensors
_version_	1718419050871128064

A movable type bioelectronics printing technology for modular fabrication of biosensors

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