Association of weight fluctuation with cardiovascular disease risk among initially obese adults

Abstract The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health...

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Autores principales:	Seogsong Jeong, Seulggie Choi, Jooyoung Chang, Kyuwoong Kim, Sung Min Kim, Seo Yun Hwang, Joung Sik Son, Gyeongsil Lee, Sang Min Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d9916e852214eb1ba49766563d3ca54
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spelling	oai:doaj.org-article:1d9916e852214eb1ba49766563d3ca542021-12-02T15:42:59ZAssociation of weight fluctuation with cardiovascular disease risk among initially obese adults10.1038/s41598-021-89666-72045-2322https://doaj.org/article/1d9916e852214eb1ba49766563d3ca542021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89666-7https://doaj.org/toc/2045-2322Abstract The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinations in three separate biennial periods were included. Participants were followed up from January 1, 2008 to the date of cardiovascular disease, death, or December 31, 2015, and categorized into 9 distinctive groups according to the BMI. Continuous weight gain showed an increased risk of overall cardiovascular disease (hazard ratio [HR], 2.36; P = 0.007), whereas weight loss after weight maintenance (HR, 0.91; P = 0.016) and weight maintenance after weight loss (HR, 0.91; P = 0.004) were ameliorative compared to the no weight change group. As for coronary heart disease, weight maintenance after weight gain was unfavorable (HR, 1.25; P = 0.004) while weight loss after weight maintenance (HR, 0.82; P < 0.001), weight cycling (HR, 0.83; P = 0.043), and weight maintenance after weight loss (HR, 0.88; P = 0.012) were beneficial. Weight maintenance after weight loss is beneficial for obese adults in terms of cardiovascular risks. In addition, weight loss is in part related to reduced risk of coronary heart disease despite weight cycling.Seogsong JeongSeulggie ChoiJooyoung ChangKyuwoong KimSung Min KimSeo Yun HwangJoung Sik SonGyeongsil LeeSang Min ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seogsong Jeong Seulggie Choi Jooyoung Chang Kyuwoong Kim Sung Min Kim Seo Yun Hwang Joung Sik Son Gyeongsil Lee Sang Min Park Association of weight fluctuation with cardiovascular disease risk among initially obese adults
description	Abstract The association of fluctuations in body mass index with cardiovascular risk in long-term is not well understood. This study aimed to investigate cardiovascular outcomes of weight fluctuation. Total of 67,101 obese adults from the Korean National Health Insurance Service who received health examinations in three separate biennial periods were included. Participants were followed up from January 1, 2008 to the date of cardiovascular disease, death, or December 31, 2015, and categorized into 9 distinctive groups according to the BMI. Continuous weight gain showed an increased risk of overall cardiovascular disease (hazard ratio [HR], 2.36; P = 0.007), whereas weight loss after weight maintenance (HR, 0.91; P = 0.016) and weight maintenance after weight loss (HR, 0.91; P = 0.004) were ameliorative compared to the no weight change group. As for coronary heart disease, weight maintenance after weight gain was unfavorable (HR, 1.25; P = 0.004) while weight loss after weight maintenance (HR, 0.82; P < 0.001), weight cycling (HR, 0.83; P = 0.043), and weight maintenance after weight loss (HR, 0.88; P = 0.012) were beneficial. Weight maintenance after weight loss is beneficial for obese adults in terms of cardiovascular risks. In addition, weight loss is in part related to reduced risk of coronary heart disease despite weight cycling.
format	article
author	Seogsong Jeong Seulggie Choi Jooyoung Chang Kyuwoong Kim Sung Min Kim Seo Yun Hwang Joung Sik Son Gyeongsil Lee Sang Min Park
author_facet	Seogsong Jeong Seulggie Choi Jooyoung Chang Kyuwoong Kim Sung Min Kim Seo Yun Hwang Joung Sik Son Gyeongsil Lee Sang Min Park
author_sort	Seogsong Jeong
title	Association of weight fluctuation with cardiovascular disease risk among initially obese adults
title_short	Association of weight fluctuation with cardiovascular disease risk among initially obese adults
title_full	Association of weight fluctuation with cardiovascular disease risk among initially obese adults
title_fullStr	Association of weight fluctuation with cardiovascular disease risk among initially obese adults
title_full_unstemmed	Association of weight fluctuation with cardiovascular disease risk among initially obese adults
title_sort	association of weight fluctuation with cardiovascular disease risk among initially obese adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d9916e852214eb1ba49766563d3ca54
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Association of weight fluctuation with cardiovascular disease risk among initially obese adults

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