Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.

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Autores principales:	Joonas A. Jamsen, Akira Sassa, Lalith Perera, David D. Shock, William A. Beard, Samuel H. Wilson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
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spelling	oai:doaj.org-article:1da597dd861e4c449ac7230ac323f30d2021-12-02T18:01:16ZStructural basis for proficient oxidized ribonucleotide insertion in double strand break repair10.1038/s41467-021-24486-x2041-1723https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24486-xhttps://doaj.org/toc/2041-1723The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.Joonas A. JamsenAkira SassaLalith PereraDavid D. ShockWilliam A. BeardSamuel H. WilsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joonas A. Jamsen Akira Sassa Lalith Perera David D. Shock William A. Beard Samuel H. Wilson Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
description	The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.
format	article
author	Joonas A. Jamsen Akira Sassa Lalith Perera David D. Shock William A. Beard Samuel H. Wilson
author_facet	Joonas A. Jamsen Akira Sassa Lalith Perera David D. Shock William A. Beard Samuel H. Wilson
author_sort	Joonas A. Jamsen
title	Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
title_short	Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
title_full	Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
title_fullStr	Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
title_full_unstemmed	Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
title_sort	structural basis for proficient oxidized ribonucleotide insertion in double strand break repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
work_keys_str_mv	AT joonasajamsen structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair AT akirasassa structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair AT lalithperera structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair AT daviddshock structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair AT williamabeard structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair AT samuelhwilson structuralbasisforproficientoxidizedribonucleotideinsertionindoublestrandbreakrepair
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Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

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