Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.

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Autores principales: Joonas A. Jamsen, Akira Sassa, Lalith Perera, David D. Shock, William A. Beard, Samuel H. Wilson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/1da597dd861e4c449ac7230ac323f30d
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