Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score

Abstract Although Ki67 labeling index is a potential predictive marker for chemotherapy benefit, its clinical utility has been limited by the lack of a standard scoring method resulting in poor interobserver reproducibility. Especially, there is no consensus on the use of average versus hotspot scor...

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Autores principales:	Soonmyung Paik, Youngmee Kwon, Moo Hyun Lee, Ji Ye Kim, Da Kyung Lee, Won Jeong Cho, Eun Young Lee, Eun Sook Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1da6a665e76f4556ac906f59f8900391
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spelling	oai:doaj.org-article:1da6a665e76f4556ac906f59f89003912021-12-02T13:30:14ZSystematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score10.1038/s41523-021-00221-z2374-4677https://doaj.org/article/1da6a665e76f4556ac906f59f89003912021-02-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00221-zhttps://doaj.org/toc/2374-4677Abstract Although Ki67 labeling index is a potential predictive marker for chemotherapy benefit, its clinical utility has been limited by the lack of a standard scoring method resulting in poor interobserver reproducibility. Especially, there is no consensus on the use of average versus hotspot score for reporting. In order to determine the best method for Ki67 scoring and validate manual scoring method proposed by the International Ki67 Working Group (IKWG), we systematically compared average versus hotspot score in 240 cases with a public domain image analysis program QuPath. We used OncotypeDx Recurrence Score (RS) as a benchmark to compare the potential clinical utility of each scoring methods. Both average and hotspot scores showed statistically significant but only modest correlation with OncotypeDx RS. Only hotspot score could meaningfully distinguish RS low-risk versus high-risk patients. However, hotspot score was less reproducible limiting its clinical utility. In summary, our data demonstrate that utility of the Ki67 labeling index is influenced by the choice of scoring method.Soonmyung PaikYoungmee KwonMoo Hyun LeeJi Ye KimDa Kyung LeeWon Jeong ChoEun Young LeeEun Sook LeeNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Soonmyung Paik Youngmee Kwon Moo Hyun Lee Ji Ye Kim Da Kyung Lee Won Jeong Cho Eun Young Lee Eun Sook Lee Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
description	Abstract Although Ki67 labeling index is a potential predictive marker for chemotherapy benefit, its clinical utility has been limited by the lack of a standard scoring method resulting in poor interobserver reproducibility. Especially, there is no consensus on the use of average versus hotspot score for reporting. In order to determine the best method for Ki67 scoring and validate manual scoring method proposed by the International Ki67 Working Group (IKWG), we systematically compared average versus hotspot score in 240 cases with a public domain image analysis program QuPath. We used OncotypeDx Recurrence Score (RS) as a benchmark to compare the potential clinical utility of each scoring methods. Both average and hotspot scores showed statistically significant but only modest correlation with OncotypeDx RS. Only hotspot score could meaningfully distinguish RS low-risk versus high-risk patients. However, hotspot score was less reproducible limiting its clinical utility. In summary, our data demonstrate that utility of the Ki67 labeling index is influenced by the choice of scoring method.
format	article
author	Soonmyung Paik Youngmee Kwon Moo Hyun Lee Ji Ye Kim Da Kyung Lee Won Jeong Cho Eun Young Lee Eun Sook Lee
author_facet	Soonmyung Paik Youngmee Kwon Moo Hyun Lee Ji Ye Kim Da Kyung Lee Won Jeong Cho Eun Young Lee Eun Sook Lee
author_sort	Soonmyung Paik
title	Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
title_short	Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
title_full	Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
title_fullStr	Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
title_full_unstemmed	Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
title_sort	systematic evaluation of scoring methods for ki67 as a surrogate for 21-gene recurrence score
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1da6a665e76f4556ac906f59f8900391
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Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score

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