Preclinical Advances of Therapies for Laminopathies

Laminopathies are a group of rare disorders due to mutation in <i>LMNA</i> gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for lamin...

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Autores principales:	Louise Benarroch, Enzo Cohen, Antonio Atalaia, Rabah Ben Yaou, Gisèle Bonne, Anne T Bertrand
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>LMNA</i> lamin A/C progerin laminopathy treatment therapy Medicine R
Acceso en línea:	https://doaj.org/article/1dac7776c7c14d8c90553a1911ea9631
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spelling	oai:doaj.org-article:1dac7776c7c14d8c90553a1911ea96312021-11-11T17:30:03ZPreclinical Advances of Therapies for Laminopathies10.3390/jcm102148342077-0383https://doaj.org/article/1dac7776c7c14d8c90553a1911ea96312021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4834https://doaj.org/toc/2077-0383Laminopathies are a group of rare disorders due to mutation in <i>LMNA</i> gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for laminopathies are not fully understood, several therapeutic approaches have been evaluated in patient cells or animal models, ranging from gene therapies to cell and drug therapies. This review is focused on these therapies with a strong focus on striated muscle laminopathies and premature ageing syndromes.Louise BenarrochEnzo CohenAntonio AtalaiaRabah Ben YaouGisèle BonneAnne T BertrandMDPI AGarticle<i>LMNA</i>lamin A/CprogerinlaminopathytreatmenttherapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4834, p 4834 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>LMNA</i> lamin A/C progerin laminopathy treatment therapy Medicine R
spellingShingle	<i>LMNA</i> lamin A/C progerin laminopathy treatment therapy Medicine R Louise Benarroch Enzo Cohen Antonio Atalaia Rabah Ben Yaou Gisèle Bonne Anne T Bertrand Preclinical Advances of Therapies for Laminopathies
description	Laminopathies are a group of rare disorders due to mutation in <i>LMNA</i> gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for laminopathies are not fully understood, several therapeutic approaches have been evaluated in patient cells or animal models, ranging from gene therapies to cell and drug therapies. This review is focused on these therapies with a strong focus on striated muscle laminopathies and premature ageing syndromes.
format	article
author	Louise Benarroch Enzo Cohen Antonio Atalaia Rabah Ben Yaou Gisèle Bonne Anne T Bertrand
author_facet	Louise Benarroch Enzo Cohen Antonio Atalaia Rabah Ben Yaou Gisèle Bonne Anne T Bertrand
author_sort	Louise Benarroch
title	Preclinical Advances of Therapies for Laminopathies
title_short	Preclinical Advances of Therapies for Laminopathies
title_full	Preclinical Advances of Therapies for Laminopathies
title_fullStr	Preclinical Advances of Therapies for Laminopathies
title_full_unstemmed	Preclinical Advances of Therapies for Laminopathies
title_sort	preclinical advances of therapies for laminopathies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1dac7776c7c14d8c90553a1911ea9631
work_keys_str_mv	AT louisebenarroch preclinicaladvancesoftherapiesforlaminopathies AT enzocohen preclinicaladvancesoftherapiesforlaminopathies AT antonioatalaia preclinicaladvancesoftherapiesforlaminopathies AT rabahbenyaou preclinicaladvancesoftherapiesforlaminopathies AT giselebonne preclinicaladvancesoftherapiesforlaminopathies AT annetbertrand preclinicaladvancesoftherapiesforlaminopathies
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Preclinical Advances of Therapies for Laminopathies

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