Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes i...

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Detalles Bibliográficos
Autores principales: Hongliang Tan, Song Guo, Ngoc-Duy Dinh, Rongcong Luo, Lin Jin, Chia-Hung Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1daf49c724184f3aac023a53cb359ed8
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Sumario:Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes in distinct domains for one-pot, tandem reactions.