Key Regulators of Autophagosome Closure

Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the f...

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Autores principales:	Wenyan Jiang, Xuechai Chen, Cuicui Ji, Wenting Zhang, Jianing Song, Jie Li, Juan Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autophagy autophagosome closure isolation membrane Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1db081a9974f4187835db54a744cb06e
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spelling	oai:doaj.org-article:1db081a9974f4187835db54a744cb06e2021-11-25T17:07:27ZKey Regulators of Autophagosome Closure10.3390/cells101128142073-4409https://doaj.org/article/1db081a9974f4187835db54a744cb06e2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2814https://doaj.org/toc/2073-4409Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.Wenyan JiangXuechai ChenCuicui JiWenting ZhangJianing SongJie LiJuan WangMDPI AGarticleautophagyautophagosomeclosureisolation membraneBiology (General)QH301-705.5ENCells, Vol 10, Iss 2814, p 2814 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autophagy autophagosome closure isolation membrane Biology (General) QH301-705.5
spellingShingle	autophagy autophagosome closure isolation membrane Biology (General) QH301-705.5 Wenyan Jiang Xuechai Chen Cuicui Ji Wenting Zhang Jianing Song Jie Li Juan Wang Key Regulators of Autophagosome Closure
description	Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.
format	article
author	Wenyan Jiang Xuechai Chen Cuicui Ji Wenting Zhang Jianing Song Jie Li Juan Wang
author_facet	Wenyan Jiang Xuechai Chen Cuicui Ji Wenting Zhang Jianing Song Jie Li Juan Wang
author_sort	Wenyan Jiang
title	Key Regulators of Autophagosome Closure
title_short	Key Regulators of Autophagosome Closure
title_full	Key Regulators of Autophagosome Closure
title_fullStr	Key Regulators of Autophagosome Closure
title_full_unstemmed	Key Regulators of Autophagosome Closure
title_sort	key regulators of autophagosome closure
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1db081a9974f4187835db54a744cb06e
work_keys_str_mv	AT wenyanjiang keyregulatorsofautophagosomeclosure AT xuechaichen keyregulatorsofautophagosomeclosure AT cuicuiji keyregulatorsofautophagosomeclosure AT wentingzhang keyregulatorsofautophagosomeclosure AT jianingsong keyregulatorsofautophagosomeclosure AT jieli keyregulatorsofautophagosomeclosure AT juanwang keyregulatorsofautophagosomeclosure
_version_	1718412699474329600

Key Regulators of Autophagosome Closure

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