Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland

Introduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and i...

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Autores principales:	Agnieszka Malinowska, Marta Muchlado, Zuzanna Ślizień, Bogdan Biedunkiewicz, Zbigniew Heleniak, Alicja Dębska-Ślizień, Leszek Tylicki
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 kidney transplant recipient post-COVID-19 syndrome long COVID-19 symptoms Medicine R
Acceso en línea:	https://doaj.org/article/1db1a4b9a2b043748a08020917131ffb
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spelling	oai:doaj.org-article:1db1a4b9a2b043748a08020917131ffb2021-11-11T17:48:39ZPost-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland10.3390/jcm102152052077-0383https://doaj.org/article/1db1a4b9a2b043748a08020917131ffb2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5205https://doaj.org/toc/2077-0383Introduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and its predictors in kidney transplant recipients (KTR) 6 months after the disease. Materials and Methods: A total of 67 KTR (38 m) with a mean age of 53.6 ± 14 years, 7.3 ± 6.4 years post-transplant were included in the cohort longitudinal study. Thirty-nine (58.2%) of them were hospitalized, but not one required invasive ventilation therapy. They were interviewed 6 months after being infected, with a series of standardized questionnaires: a self-reported symptoms questionnaire, the modified British Medical Research Council (mMRC) dyspnea scale, EQ-5D-5L questionnaire, and EQ-VAS scale. Results: Post-COVID-19 syndrome was diagnosed in 70.1% of KTR and 26.9% of them reported at least three persistent symptoms. The most common symptoms were fatigue (43.3%), hair loss (31.3%), memory impairment (11.9%), muscle aches, and headaches (11.9%). Dyspnea with an mMRC scale grade of at least 1 was reported by 34.3% patients vs. 14.9% before infection; 47.8% stated that they still feel worse than before the disease. Mean EQ-VAS scores were 64.83 vs. 73.34 before infection. The persistent symptoms are more frequent in older patients and those with greater comorbidity. Conclusions: Persistent symptoms of post-COVID-19 syndrome are present in the majority of KTR, which highlights the need for long-term follow-up as well as diagnostic and rehabilitation programs.Agnieszka MalinowskaMarta MuchladoZuzanna ŚlizieńBogdan BiedunkiewiczZbigniew HeleniakAlicja Dębska-ŚlizieńLeszek TylickiMDPI AGarticleCOVID-19kidney transplant recipientpost-COVID-19 syndromelong COVID-19 symptomsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5205, p 5205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 kidney transplant recipient post-COVID-19 syndrome long COVID-19 symptoms Medicine R
spellingShingle	COVID-19 kidney transplant recipient post-COVID-19 syndrome long COVID-19 symptoms Medicine R Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
description	Introduction: Patients after SARS-CoV-2 infection frequently face “Post-COVID-19 Syndrome”, defined by symptoms that develop during or after COVID-19, continue for more than 12 weeks, and are not explained by an alternative diagnosis. We aimed to evaluate the presence of post-COVID-19 syndrome and its predictors in kidney transplant recipients (KTR) 6 months after the disease. Materials and Methods: A total of 67 KTR (38 m) with a mean age of 53.6 ± 14 years, 7.3 ± 6.4 years post-transplant were included in the cohort longitudinal study. Thirty-nine (58.2%) of them were hospitalized, but not one required invasive ventilation therapy. They were interviewed 6 months after being infected, with a series of standardized questionnaires: a self-reported symptoms questionnaire, the modified British Medical Research Council (mMRC) dyspnea scale, EQ-5D-5L questionnaire, and EQ-VAS scale. Results: Post-COVID-19 syndrome was diagnosed in 70.1% of KTR and 26.9% of them reported at least three persistent symptoms. The most common symptoms were fatigue (43.3%), hair loss (31.3%), memory impairment (11.9%), muscle aches, and headaches (11.9%). Dyspnea with an mMRC scale grade of at least 1 was reported by 34.3% patients vs. 14.9% before infection; 47.8% stated that they still feel worse than before the disease. Mean EQ-VAS scores were 64.83 vs. 73.34 before infection. The persistent symptoms are more frequent in older patients and those with greater comorbidity. Conclusions: Persistent symptoms of post-COVID-19 syndrome are present in the majority of KTR, which highlights the need for long-term follow-up as well as diagnostic and rehabilitation programs.
format	article
author	Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki
author_facet	Agnieszka Malinowska Marta Muchlado Zuzanna Ślizień Bogdan Biedunkiewicz Zbigniew Heleniak Alicja Dębska-Ślizień Leszek Tylicki
author_sort	Agnieszka Malinowska
title	Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
title_short	Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
title_full	Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
title_fullStr	Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
title_full_unstemmed	Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland
title_sort	post-covid-19 sydrome and decrease in health-related quality of life in kidney transplant recipients after sars-cov-2 infection—a cohort longitudinal study from the north of poland
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1db1a4b9a2b043748a08020917131ffb
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Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection—A Cohort Longitudinal Study from the North of Poland

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