Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma

Abstract SOX9 (Sex-determining region Y Box 9) is a well-characterized transcription factor that is a marker for progenitor cells in various tissues. In the liver, cells delineated by SOX9 are responsible for regenerating liver parenchyma when cell proliferation is impaired following chronic injury....

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Autores principales: Jingyu Chen, Anketse Debebe, Ni Zeng, Janel Kopp, Lina He, Maike Sander, Bangyan L. Stiles
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1db28909f5914c96b75d5b4abc666999
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