Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells

Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppressio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Song Chen, Lijun Fang, Wei Guo, Yushan Zhou, Gang Yu, Wenwen Li, Kui Dong, Jingru Liu, Yuechen Luo, Bing Wang, Zhonglong Li, Chunxiao Zhao, Zhina Sun, Yue Shen, Qibing Leng, Dongming Zhou, Zhongchao Han, Huifang Huang, He Ren, Guogang Xu, Xiaoming Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1db2967ef1334994b79d8893a7fb9ef8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1db2967ef1334994b79d8893a7fb9ef8
record_format	dspace
spelling	oai:doaj.org-article:1db2967ef1334994b79d8893a7fb9ef82021-12-02T14:38:50ZControl of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells10.1038/s41467-018-07545-82041-1723https://doaj.org/article/1db2967ef1334994b79d8893a7fb9ef82018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07545-8https://doaj.org/toc/2041-1723Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.Song ChenLijun FangWei GuoYushan ZhouGang YuWenwen LiKui DongJingru LiuYuechen LuoBing WangZhonglong LiChunxiao ZhaoZhina SunYue ShenQibing LengDongming ZhouZhongchao HanHuifang HuangHe RenGuogang XuXiaoming FengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Chen Lijun Fang Wei Guo Yushan Zhou Gang Yu Wenwen Li Kui Dong Jingru Liu Yuechen Luo Bing Wang Zhonglong Li Chunxiao Zhao Zhina Sun Yue Shen Qibing Leng Dongming Zhou Zhongchao Han Huifang Huang He Ren Guogang Xu Xiaoming Feng Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
description	Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.
format	article
author	Song Chen Lijun Fang Wei Guo Yushan Zhou Gang Yu Wenwen Li Kui Dong Jingru Liu Yuechen Luo Bing Wang Zhonglong Li Chunxiao Zhao Zhina Sun Yue Shen Qibing Leng Dongming Zhou Zhongchao Han Huifang Huang He Ren Guogang Xu Xiaoming Feng
author_facet	Song Chen Lijun Fang Wei Guo Yushan Zhou Gang Yu Wenwen Li Kui Dong Jingru Liu Yuechen Luo Bing Wang Zhonglong Li Chunxiao Zhao Zhina Sun Yue Shen Qibing Leng Dongming Zhou Zhongchao Han Huifang Huang He Ren Guogang Xu Xiaoming Feng
author_sort	Song Chen
title	Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
title_short	Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
title_full	Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
title_fullStr	Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
title_full_unstemmed	Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells
title_sort	control of treg cell homeostasis and immune equilibrium by lkb1 in dendritic cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1db2967ef1334994b79d8893a7fb9ef8
work_keys_str_mv	AT songchen controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT lijunfang controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT weiguo controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT yushanzhou controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT gangyu controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT wenwenli controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT kuidong controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT jingruliu controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT yuechenluo controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT bingwang controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT zhonglongli controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT chunxiaozhao controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT zhinasun controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT yueshen controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT qibingleng controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT dongmingzhou controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT zhongchaohan controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT huifanghuang controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT heren controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT guogangxu controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells AT xiaomingfeng controloftregcellhomeostasisandimmuneequilibriumbylkb1indendriticcells
_version_	1718390817245102080

Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells

Ejemplares similares