An update on the use of Atripla® in the treatment of HIV in the United States
Michael A Horberg1, Daniel B Klein21HIV Interregional Initiative, Kaiser Permanente, Oakland, California, USA; 2Department of Infectious Diseases, Kaiser Permanente Hayward Medical Center, Hayward, California, USAAbstract: Atripla® (Gilead Sciences Inc, Foster City, CA, USA and Bristol-M...
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Dove Medical Press
2010
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oai:doaj.org-article:1db7236ac07249adbbb8302f8067db942021-12-02T04:51:05ZAn update on the use of Atripla® in the treatment of HIV in the United States1179-1373https://doaj.org/article/1db7236ac07249adbbb8302f8067db942010-06-01T00:00:00Zhttp://www.dovepress.com/an-update-on-the-use-of-atriplareg-in-the-treatment-of-hiv-in-the-unit-a4615https://doaj.org/toc/1179-1373Michael A Horberg1, Daniel B Klein21HIV Interregional Initiative, Kaiser Permanente, Oakland, California, USA; 2Department of Infectious Diseases, Kaiser Permanente Hayward Medical Center, Hayward, California, USAAbstract: Atripla® (Gilead Sciences Inc, Foster City, CA, USA and Bristol-Myers Squibb, New York City, NY, USA) is a coformulated single pill composed of efavirenz, emtricitabine, and tenofovir disoproxil, intended as a once-daily potent combination antiretroviral therapeutic agent. Its efficacy is equivalent to the 3 component drugs taken in a combination as single medications. The coformulated antiretroviral regimen can be quite effective in patients whose human immunodeficiency virus is sensitive to all 3 components of Atripla. However, women at risk of pregnancy, already pregnant, or nursing mothers should not take Atripla, due to the teratogenic potential of the efavirenz moiety. Adverse effects are similar to those seen with the constituent medications, including potential central nervous system effects and renal toxicity. Since its US Food and Drug administration approval, prescriptions for Atripla have increased steadily.Keywords: tenofovir, efavirenz, emtricitabine, antiretroviral therapy Michael A HorbergDaniel B KleinDove Medical PressarticleImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol 2010, Iss default, Pp 135-140 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Michael A Horberg Daniel B Klein An update on the use of Atripla® in the treatment of HIV in the United States |
| description |
Michael A Horberg1, Daniel B Klein21HIV Interregional Initiative, Kaiser Permanente, Oakland, California, USA; 2Department of Infectious Diseases, Kaiser Permanente Hayward Medical Center, Hayward, California, USAAbstract: Atripla® (Gilead Sciences Inc, Foster City, CA, USA and Bristol-Myers Squibb, New York City, NY, USA) is a coformulated single pill composed of efavirenz, emtricitabine, and tenofovir disoproxil, intended as a once-daily potent combination antiretroviral therapeutic agent. Its efficacy is equivalent to the 3 component drugs taken in a combination as single medications. The coformulated antiretroviral regimen can be quite effective in patients whose human immunodeficiency virus is sensitive to all 3 components of Atripla. However, women at risk of pregnancy, already pregnant, or nursing mothers should not take Atripla, due to the teratogenic potential of the efavirenz moiety. Adverse effects are similar to those seen with the constituent medications, including potential central nervous system effects and renal toxicity. Since its US Food and Drug administration approval, prescriptions for Atripla have increased steadily.Keywords: tenofovir, efavirenz, emtricitabine, antiretroviral therapy |
| format |
article |
| author |
Michael A Horberg Daniel B Klein |
| author_facet |
Michael A Horberg Daniel B Klein |
| author_sort |
Michael A Horberg |
| title |
An update on the use of Atripla® in the treatment of HIV in the United States |
| title_short |
An update on the use of Atripla® in the treatment of HIV in the United States |
| title_full |
An update on the use of Atripla® in the treatment of HIV in the United States |
| title_fullStr |
An update on the use of Atripla® in the treatment of HIV in the United States |
| title_full_unstemmed |
An update on the use of Atripla® in the treatment of HIV in the United States |
| title_sort |
update on the use of atripla® in the treatment of hiv in the united states |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/1db7236ac07249adbbb8302f8067db94 |
| work_keys_str_mv |
AT michaelahorberg anupdateontheuseofatriplaampreginthetreatmentofhivintheunitedstates AT danielbklein anupdateontheuseofatriplaampreginthetreatmentofhivintheunitedstates AT michaelahorberg updateontheuseofatriplaampreginthetreatmentofhivintheunitedstates AT danielbklein updateontheuseofatriplaampreginthetreatmentofhivintheunitedstates |
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