Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy
Abstract Obstructive sleep apnea (OSA) is much common and associated with worse clinical outcomes in patients with hypertrophic cardiomyopathy (HCM), however, the diagnosis of OSA in HCM is still insufficient. We aim to investigate the clinical predictors of OSA in a large series of patients with HC...
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2021
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oai:doaj.org-article:1dbb4b55a23f4a2c95cf76bf4d5908682021-12-02T16:32:02ZClinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy10.1038/s41598-021-93039-52045-2322https://doaj.org/article/1dbb4b55a23f4a2c95cf76bf4d5908682021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93039-5https://doaj.org/toc/2045-2322Abstract Obstructive sleep apnea (OSA) is much common and associated with worse clinical outcomes in patients with hypertrophic cardiomyopathy (HCM), however, the diagnosis of OSA in HCM is still insufficient. We aim to investigate the clinical predictors of OSA in a large series of patients with HCM. A total of 589 patients with HCM who underwent sleep evaluations were retrospectively enrolled. Data from clinical characteristics and polysomnography studies were recorded. OSA was present in 346 patients (58.7%). Patients who had OSA were older, more likely to be male and had more clinical comorbidities such as hypertension, atrial fibrillation and cardiac remodeling. Multivariate logistic analyses showed that male, age, body mass index, hypertension and left ventricular outflow tract obstruction were significant factors associated with OSA. The area under the ROC curve (AUC) was 0.78 (95% CI 0.74–0.82; P < 0.001). These factors were also able to identify moderate to severe OSA with an AUC of 0.77 (95% CI 0.73–0.81; P < 0.001). These findings suggest that identifying HCM patients with high risk for OSA is feasible using characteristics from clinical practices and clinicians should have no hesitate to conduct sleep test in these patients.Haobo XuJuan WangJiansong YuanChao GuoFenghuan HuWeixian YangLei SongXiaoliang LuoRong LiuJingang CuiShengwen LiuYushi ChunYunhu SongShubin QiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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Medicine R Science Q Haobo Xu Juan Wang Jiansong Yuan Chao Guo Fenghuan Hu Weixian Yang Lei Song Xiaoliang Luo Rong Liu Jingang Cui Shengwen Liu Yushi Chun Yunhu Song Shubin Qiao Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| description |
Abstract Obstructive sleep apnea (OSA) is much common and associated with worse clinical outcomes in patients with hypertrophic cardiomyopathy (HCM), however, the diagnosis of OSA in HCM is still insufficient. We aim to investigate the clinical predictors of OSA in a large series of patients with HCM. A total of 589 patients with HCM who underwent sleep evaluations were retrospectively enrolled. Data from clinical characteristics and polysomnography studies were recorded. OSA was present in 346 patients (58.7%). Patients who had OSA were older, more likely to be male and had more clinical comorbidities such as hypertension, atrial fibrillation and cardiac remodeling. Multivariate logistic analyses showed that male, age, body mass index, hypertension and left ventricular outflow tract obstruction were significant factors associated with OSA. The area under the ROC curve (AUC) was 0.78 (95% CI 0.74–0.82; P < 0.001). These factors were also able to identify moderate to severe OSA with an AUC of 0.77 (95% CI 0.73–0.81; P < 0.001). These findings suggest that identifying HCM patients with high risk for OSA is feasible using characteristics from clinical practices and clinicians should have no hesitate to conduct sleep test in these patients. |
| format |
article |
| author |
Haobo Xu Juan Wang Jiansong Yuan Chao Guo Fenghuan Hu Weixian Yang Lei Song Xiaoliang Luo Rong Liu Jingang Cui Shengwen Liu Yushi Chun Yunhu Song Shubin Qiao |
| author_facet |
Haobo Xu Juan Wang Jiansong Yuan Chao Guo Fenghuan Hu Weixian Yang Lei Song Xiaoliang Luo Rong Liu Jingang Cui Shengwen Liu Yushi Chun Yunhu Song Shubin Qiao |
| author_sort |
Haobo Xu |
| title |
Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| title_short |
Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| title_full |
Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| title_fullStr |
Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| title_full_unstemmed |
Clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| title_sort |
clinical predictors of the presence of obstructive sleep apnea in patients with hypertrophic cardiomyopathy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1dbb4b55a23f4a2c95cf76bf4d590868 |
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