Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials

Abstract By providing a bidirectional communication channel between neural tissues and a biomedical device, it is envisaged that neural interfaces will be fundamental in the future diagnosis and treatment of neurological disorders. Due to the mechanical mismatch between neural tissue and metallic ne...

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Autores principales:	Katarzyna Krukiewicz, James Britton, Daria Więcławska, Małgorzata Skorupa, Jorge Fernandez, Jose-Ramon Sarasua, Manus J. P. Biggs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1dbc09d730854761bbc24a3cc9696955
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spelling	oai:doaj.org-article:1dbc09d730854761bbc24a3cc96969552021-12-02T14:01:21ZElectrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials10.1038/s41598-020-80361-72045-2322https://doaj.org/article/1dbc09d730854761bbc24a3cc96969552021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80361-7https://doaj.org/toc/2045-2322Abstract By providing a bidirectional communication channel between neural tissues and a biomedical device, it is envisaged that neural interfaces will be fundamental in the future diagnosis and treatment of neurological disorders. Due to the mechanical mismatch between neural tissue and metallic neural electrodes, soft electrically conducting materials are of great benefit in promoting chronic device functionality. In this study, carbon nanotubes (CNT), silver nanowires (AgNW) and poly(hydroxymethyl 3,4-ethylenedioxythiophene) microspheres (MSP) were employed as conducting fillers within a poly(ε-decalactone) (EDL) matrix, to form a soft and electrically conducting composite. The effect of a filler type on the electrical percolation threshold, and composite biocompatibility was investigated in vitro. EDL-based composites exhibited favourable electrochemical characteristics: EDL/CNT—the lowest film resistance (1.2 ± 0.3 kΩ), EDL/AgNW—the highest charge storage capacity (10.7 ± 0.3 mC cm− 2), and EDL/MSP—the highest interphase capacitance (1478.4 ± 92.4 µF cm−2). All investigated composite surfaces were found to be biocompatible, and to reduce the presence of reactive astrocytes relative to control electrodes. The results of this work clearly demonstrated the ability of high aspect ratio structures to form an extended percolation network within a polyester matrix, resulting in the formulation of composites with advantageous mechanical, electrochemical and biocompatibility properties.Katarzyna KrukiewiczJames BrittonDaria WięcławskaMałgorzata SkorupaJorge FernandezJose-Ramon SarasuaManus J. P. BiggsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna Krukiewicz James Britton Daria Więcławska Małgorzata Skorupa Jorge Fernandez Jose-Ramon Sarasua Manus J. P. Biggs Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
description	Abstract By providing a bidirectional communication channel between neural tissues and a biomedical device, it is envisaged that neural interfaces will be fundamental in the future diagnosis and treatment of neurological disorders. Due to the mechanical mismatch between neural tissue and metallic neural electrodes, soft electrically conducting materials are of great benefit in promoting chronic device functionality. In this study, carbon nanotubes (CNT), silver nanowires (AgNW) and poly(hydroxymethyl 3,4-ethylenedioxythiophene) microspheres (MSP) were employed as conducting fillers within a poly(ε-decalactone) (EDL) matrix, to form a soft and electrically conducting composite. The effect of a filler type on the electrical percolation threshold, and composite biocompatibility was investigated in vitro. EDL-based composites exhibited favourable electrochemical characteristics: EDL/CNT—the lowest film resistance (1.2 ± 0.3 kΩ), EDL/AgNW—the highest charge storage capacity (10.7 ± 0.3 mC cm− 2), and EDL/MSP—the highest interphase capacitance (1478.4 ± 92.4 µF cm−2). All investigated composite surfaces were found to be biocompatible, and to reduce the presence of reactive astrocytes relative to control electrodes. The results of this work clearly demonstrated the ability of high aspect ratio structures to form an extended percolation network within a polyester matrix, resulting in the formulation of composites with advantageous mechanical, electrochemical and biocompatibility properties.
format	article
author	Katarzyna Krukiewicz James Britton Daria Więcławska Małgorzata Skorupa Jorge Fernandez Jose-Ramon Sarasua Manus J. P. Biggs
author_facet	Katarzyna Krukiewicz James Britton Daria Więcławska Małgorzata Skorupa Jorge Fernandez Jose-Ramon Sarasua Manus J. P. Biggs
author_sort	Katarzyna Krukiewicz
title	Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
title_short	Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
title_full	Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
title_fullStr	Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
title_full_unstemmed	Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
title_sort	electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1dbc09d730854761bbc24a3cc9696955
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Electrical percolation in extrinsically conducting, poly(ε-decalactone) composite neural interface materials

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