PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.

PPAR-alpha agonists as novel antiepileptic drugs: preclinical findings.

Nicotinic acetylcholine receptors (nAChRs) are involved in seizure mechanisms. Hence, nocturnal frontal lobe epilepsy was the first idiopathic epilepsy linked with specific mutations in α4 or β2 nAChR subunit genes. These mutations confer gain of function to nAChRs by increasing sensitivity toward a...

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Autores principales: Monica Puligheddu, Giuliano Pillolla, Miriam Melis, Salvatore Lecca, Francesco Marrosu, Maria Graziella De Montis, Simona Scheggi, Gianfranca Carta, Elisabetta Murru, Sonia Aroni, Anna Lisa Muntoni, Marco Pistis
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/1dbc15029d9a4fd188a75a6d01878efa
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https://doaj.org/article/1dbc15029d9a4fd188a75a6d01878efa

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