High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China
Background: Despite the insupportable burden caused by the human papillomavirus (HPV) and high vaccine acceptability, vaccination programs are not currently available for men who have sex with men (MSM). We aimed to assess HPV infection by examining the willingness for vaccination among MSM and cost...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1dbc4c92254e461685cbf6c98593f6f92021-11-19T05:22:52ZHigh Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China2296-858X10.3389/fmed.2021.763564https://doaj.org/article/1dbc4c92254e461685cbf6c98593f6f92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.763564/fullhttps://doaj.org/toc/2296-858XBackground: Despite the insupportable burden caused by the human papillomavirus (HPV) and high vaccine acceptability, vaccination programs are not currently available for men who have sex with men (MSM). We aimed to assess HPV infection by examining the willingness for vaccination among MSM and cost-effectiveness of the Chinese 2-valent HPV vaccine.Methods: We recruited MSM in Shenyang, China between July and December 2020 to conduct anal HPV testing and an online survey regarding HPV-related knowledge and vaccine acceptability. We performed a cost-effectiveness analysis to evaluate the incremental cost-effectiveness ratios (ICERs) of the Chinese 2-valent HPV vaccine.Results: A total of 234 participants completed the online survey; of those, 203 were successfully tested for HPV. The median age was 30 years [interquartile range (IQR): 23–38 years]. Most participants had at least undergraduate education (136/234, 58.1%). The acceptability rate for the free HPV vaccine was 57.7% (135/234). The prevalence of HPV types 16 and 18 was 14.9% (18/121) and 26.8% (22/82) in the willing and unwilling to vaccinate groups, respectively (P > 0.05). The prevalence of high-risk HPV among participants aged <30 and ≥50 years was 48.6 and 38.9%, respectively. Using the Chinese per capita gross domestic product (GDP) as a threshold, the Chinese 2-valent HPV vaccine would be a “very cost-effective” strategy, with an ICER value of USD 4,411. This evidence showed that the Chinese 2-valent HPV vaccine was more cost-effective than other imported vaccines.Conclusions: Targeted strategies should be utilized in MSM with different rates of vaccine acceptability. A pilot HPV vaccination program based on the Chinese 2-valent HPV vaccine for MSM is urgently warranted to reduce the burden of HPV and anal cancer.Ze-Hao YeZe-Hao YeZe-Hao YeZe-Hao YeZhao-Zhen LiuZhao-Zhen LiuZhao-Zhen LiuZhao-Zhen LiuSi-Tong CuiSi-Tong CuiSi-Tong CuiSi-Tong CuiZhen-Xing ChuZhen-Xing ChuZhen-Xing ChuZhen-Xing ChuYong-Jun JiangYong-Jun JiangYong-Jun JiangYong-Jun JiangJun-Jie XuJun-Jie XuJun-Jie XuJun-Jie XuQing-Hai HuQing-Hai HuQing-Hai HuQing-Hai HuHong ShangHong ShangHong ShangHong ShangFrontiers Media S.A.articlehuman papillomavirusvaccinemen who have sex with menacceptabilitycost-effectivenessChinaMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021) |
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human papillomavirus vaccine men who have sex with men acceptability cost-effectiveness China Medicine (General) R5-920 |
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human papillomavirus vaccine men who have sex with men acceptability cost-effectiveness China Medicine (General) R5-920 Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Si-Tong Cui Si-Tong Cui Si-Tong Cui Si-Tong Cui Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Hong Shang Hong Shang Hong Shang Hong Shang High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| description |
Background: Despite the insupportable burden caused by the human papillomavirus (HPV) and high vaccine acceptability, vaccination programs are not currently available for men who have sex with men (MSM). We aimed to assess HPV infection by examining the willingness for vaccination among MSM and cost-effectiveness of the Chinese 2-valent HPV vaccine.Methods: We recruited MSM in Shenyang, China between July and December 2020 to conduct anal HPV testing and an online survey regarding HPV-related knowledge and vaccine acceptability. We performed a cost-effectiveness analysis to evaluate the incremental cost-effectiveness ratios (ICERs) of the Chinese 2-valent HPV vaccine.Results: A total of 234 participants completed the online survey; of those, 203 were successfully tested for HPV. The median age was 30 years [interquartile range (IQR): 23–38 years]. Most participants had at least undergraduate education (136/234, 58.1%). The acceptability rate for the free HPV vaccine was 57.7% (135/234). The prevalence of HPV types 16 and 18 was 14.9% (18/121) and 26.8% (22/82) in the willing and unwilling to vaccinate groups, respectively (P > 0.05). The prevalence of high-risk HPV among participants aged <30 and ≥50 years was 48.6 and 38.9%, respectively. Using the Chinese per capita gross domestic product (GDP) as a threshold, the Chinese 2-valent HPV vaccine would be a “very cost-effective” strategy, with an ICER value of USD 4,411. This evidence showed that the Chinese 2-valent HPV vaccine was more cost-effective than other imported vaccines.Conclusions: Targeted strategies should be utilized in MSM with different rates of vaccine acceptability. A pilot HPV vaccination program based on the Chinese 2-valent HPV vaccine for MSM is urgently warranted to reduce the burden of HPV and anal cancer. |
| format |
article |
| author |
Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Si-Tong Cui Si-Tong Cui Si-Tong Cui Si-Tong Cui Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Hong Shang Hong Shang Hong Shang Hong Shang |
| author_facet |
Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Ze-Hao Ye Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Zhao-Zhen Liu Si-Tong Cui Si-Tong Cui Si-Tong Cui Si-Tong Cui Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Zhen-Xing Chu Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Yong-Jun Jiang Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Jun-Jie Xu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Qing-Hai Hu Hong Shang Hong Shang Hong Shang Hong Shang |
| author_sort |
Ze-Hao Ye |
| title |
High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| title_short |
High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| title_full |
High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| title_fullStr |
High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| title_full_unstemmed |
High Human Papillomavirus Vaccine Acceptability and Cost-Effectiveness of the Chinese 2-Valent Vaccine Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China |
| title_sort |
high human papillomavirus vaccine acceptability and cost-effectiveness of the chinese 2-valent vaccine among men who have sex with men: a cross-sectional study in shenyang, china |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1dbc4c92254e461685cbf6c98593f6f9 |
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