Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I and CD8 T cells, and is associated with resista...
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Nature Portfolio
2021
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oai:doaj.org-article:1dbc726f512b49e4900c71d53883f0cc2021-12-02T14:01:25ZTumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy10.1038/s41467-020-20600-72041-1723https://doaj.org/article/1dbc726f512b49e4900c71d53883f0cc2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20600-7https://doaj.org/toc/2041-1723Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I and CD8 T cells, and is associated with resistance to ICT, which can be reversed by c-kit inhibitor treatment.Rajasekharan SomasundaramThomas ConnellyRobin ChoiHyeree ChoiAnastasia SamarkinaLing LiElizabeth GregorioYeqing ChenRohit ThakurMohamed Abdel-MohsenMarilda BeqiriMeaghan KiernanMichela PeregoFang WangMin XiaoPatricia BraffordXue YangXiaowei XuAnthony SecretoGwenn Danet-DesnoyersDaniel TraumKlaus H. KaestnerAlexander C. HuangDenitsa HristovaJoshua WangMizuho Fukunaga-KalabisClemens KreplerFang Ping-ChenXiangyang ZhouAlexis GutierrezVito W. RebeccaPrashanthi VontedduFarokh DotiwalaShashi BalaSonali MajumdarHarsh DweepJayamanna WickramasingheAndrew V. KossenkovJorge Reyes-ArbujasKenisha SantiagoTran NguyenJohannes GrissFrederick KeeneyJames HaydenBrian J. GavinDavid WeinerLuis J. MontanerQin LiuLukas PeifferJürgen BeckerElizabeth M. BurtonMichael A. DaviesMichael T. TetzlaffKar MuthumaniJennifer A. WargoDmitry GabrilovichMeenhard HerlynNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
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Science Q |
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Science Q Rajasekharan Somasundaram Thomas Connelly Robin Choi Hyeree Choi Anastasia Samarkina Ling Li Elizabeth Gregorio Yeqing Chen Rohit Thakur Mohamed Abdel-Mohsen Marilda Beqiri Meaghan Kiernan Michela Perego Fang Wang Min Xiao Patricia Brafford Xue Yang Xiaowei Xu Anthony Secreto Gwenn Danet-Desnoyers Daniel Traum Klaus H. Kaestner Alexander C. Huang Denitsa Hristova Joshua Wang Mizuho Fukunaga-Kalabis Clemens Krepler Fang Ping-Chen Xiangyang Zhou Alexis Gutierrez Vito W. Rebecca Prashanthi Vonteddu Farokh Dotiwala Shashi Bala Sonali Majumdar Harsh Dweep Jayamanna Wickramasinghe Andrew V. Kossenkov Jorge Reyes-Arbujas Kenisha Santiago Tran Nguyen Johannes Griss Frederick Keeney James Hayden Brian J. Gavin David Weiner Luis J. Montaner Qin Liu Lukas Peiffer Jürgen Becker Elizabeth M. Burton Michael A. Davies Michael T. Tetzlaff Kar Muthumani Jennifer A. Wargo Dmitry Gabrilovich Meenhard Herlyn Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| description |
Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates vary. Here the authors show, in mouse models, that tumor-infiltrating mast cells colocalize with regulatory T cells, coincide with local reduction of MHC-I and CD8 T cells, and is associated with resistance to ICT, which can be reversed by c-kit inhibitor treatment. |
| format |
article |
| author |
Rajasekharan Somasundaram Thomas Connelly Robin Choi Hyeree Choi Anastasia Samarkina Ling Li Elizabeth Gregorio Yeqing Chen Rohit Thakur Mohamed Abdel-Mohsen Marilda Beqiri Meaghan Kiernan Michela Perego Fang Wang Min Xiao Patricia Brafford Xue Yang Xiaowei Xu Anthony Secreto Gwenn Danet-Desnoyers Daniel Traum Klaus H. Kaestner Alexander C. Huang Denitsa Hristova Joshua Wang Mizuho Fukunaga-Kalabis Clemens Krepler Fang Ping-Chen Xiangyang Zhou Alexis Gutierrez Vito W. Rebecca Prashanthi Vonteddu Farokh Dotiwala Shashi Bala Sonali Majumdar Harsh Dweep Jayamanna Wickramasinghe Andrew V. Kossenkov Jorge Reyes-Arbujas Kenisha Santiago Tran Nguyen Johannes Griss Frederick Keeney James Hayden Brian J. Gavin David Weiner Luis J. Montaner Qin Liu Lukas Peiffer Jürgen Becker Elizabeth M. Burton Michael A. Davies Michael T. Tetzlaff Kar Muthumani Jennifer A. Wargo Dmitry Gabrilovich Meenhard Herlyn |
| author_facet |
Rajasekharan Somasundaram Thomas Connelly Robin Choi Hyeree Choi Anastasia Samarkina Ling Li Elizabeth Gregorio Yeqing Chen Rohit Thakur Mohamed Abdel-Mohsen Marilda Beqiri Meaghan Kiernan Michela Perego Fang Wang Min Xiao Patricia Brafford Xue Yang Xiaowei Xu Anthony Secreto Gwenn Danet-Desnoyers Daniel Traum Klaus H. Kaestner Alexander C. Huang Denitsa Hristova Joshua Wang Mizuho Fukunaga-Kalabis Clemens Krepler Fang Ping-Chen Xiangyang Zhou Alexis Gutierrez Vito W. Rebecca Prashanthi Vonteddu Farokh Dotiwala Shashi Bala Sonali Majumdar Harsh Dweep Jayamanna Wickramasinghe Andrew V. Kossenkov Jorge Reyes-Arbujas Kenisha Santiago Tran Nguyen Johannes Griss Frederick Keeney James Hayden Brian J. Gavin David Weiner Luis J. Montaner Qin Liu Lukas Peiffer Jürgen Becker Elizabeth M. Burton Michael A. Davies Michael T. Tetzlaff Kar Muthumani Jennifer A. Wargo Dmitry Gabrilovich Meenhard Herlyn |
| author_sort |
Rajasekharan Somasundaram |
| title |
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| title_short |
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| title_full |
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| title_fullStr |
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| title_full_unstemmed |
Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy |
| title_sort |
tumor-infiltrating mast cells are associated with resistance to anti-pd-1 therapy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1dbc726f512b49e4900c71d53883f0cc |
| work_keys_str_mv |
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