Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension

Kenji Inoue1, Minako Shiokawa1, Michitaka Sugahara1, Risako Higa1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 2Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively investigate adverse reactions to bimatoprost in Japanese...

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Autores principales:	Inoue K, Shiokawa M, Sugahara M, Higa R, Wakakura M, Tomita G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1dc51342b2524e01aeb6694edda7e1ac
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spelling	oai:doaj.org-article:1dc51342b2524e01aeb6694edda7e1ac2021-12-02T03:12:50ZIris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension1177-54671177-5483https://doaj.org/article/1dc51342b2524e01aeb6694edda7e1ac2012-01-01T00:00:00Zhttp://www.dovepress.com/iris-and-periocular-adverse-reactions-to-bimatoprost-in-japanese-patie-a9048https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kenji Inoue1, Minako Shiokawa1, Michitaka Sugahara1, Risako Higa1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 2Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes to adverse reactions via a questionnaire.Methods: Fifty-two Japanese patients with glaucoma or ocular hypertension were enrolled. Iridial, eyelid, and eyelash photographs were taken before and at 6 months after bimatoprost treatment. Increase in eyelid pigmentation, iridial pigmentation, eyelash growth and bristle, and vellus hair of the lid was assessed from the photographs. Questionnaires completed by patients provided insight into their subjective judgment of adverse reactions.Results: Increase in eyelash bristle (53.8%), iris pigmentation (50.0%), eyelash growth (46.2%), vellus hair of the lid (40.4%), and eyelid pigmentation (7.7%) was evident after bimatoprost treatment. The objective and subjective assessments were in agreement in terms of increase in eyelash bristle, eyelash growth, and increase in vellus hair of the lid.Conclusion: Most patients were conscious of these adverse reactions. Before administering bimatoprost, sufficient explanation of potential adverse reactions should be provided; after initiating treatment, careful observation is required.Keywords: bimatoprost, adverse reaction, eyelid pigmentation, changes in eyelashes, iris pigmentation&nbsp;Inoue KShiokawa MSugahara MHiga RWakakura MTomita GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 111-116 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Inoue K Shiokawa M Sugahara M Higa R Wakakura M Tomita G Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
description	Kenji Inoue1, Minako Shiokawa1, Michitaka Sugahara1, Risako Higa1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo, Japan; 2Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively investigate adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension. We also examined patient attitudes to adverse reactions via a questionnaire.Methods: Fifty-two Japanese patients with glaucoma or ocular hypertension were enrolled. Iridial, eyelid, and eyelash photographs were taken before and at 6 months after bimatoprost treatment. Increase in eyelid pigmentation, iridial pigmentation, eyelash growth and bristle, and vellus hair of the lid was assessed from the photographs. Questionnaires completed by patients provided insight into their subjective judgment of adverse reactions.Results: Increase in eyelash bristle (53.8%), iris pigmentation (50.0%), eyelash growth (46.2%), vellus hair of the lid (40.4%), and eyelid pigmentation (7.7%) was evident after bimatoprost treatment. The objective and subjective assessments were in agreement in terms of increase in eyelash bristle, eyelash growth, and increase in vellus hair of the lid.Conclusion: Most patients were conscious of these adverse reactions. Before administering bimatoprost, sufficient explanation of potential adverse reactions should be provided; after initiating treatment, careful observation is required.Keywords: bimatoprost, adverse reaction, eyelid pigmentation, changes in eyelashes, iris pigmentation&nbsp;
format	article
author	Inoue K Shiokawa M Sugahara M Higa R Wakakura M Tomita G
author_facet	Inoue K Shiokawa M Sugahara M Higa R Wakakura M Tomita G
author_sort	Inoue K
title	Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
title_short	Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
title_full	Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
title_fullStr	Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
title_full_unstemmed	Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension
title_sort	iris and periocular adverse reactions to bimatoprost in japanese patients with glaucoma or ocular hypertension
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/1dc51342b2524e01aeb6694edda7e1ac
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Iris and periocular adverse reactions to bimatoprost in Japanese patients with glaucoma or ocular hypertension

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