Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats

Abstract The therapeutic effects of iron, zinc and magnesium trace elements, as well as rifaximin were investigated and compared in HE rats. In this study, HE rats were treated with either ferrous sulfate (HE-Fe, 30 mg/kg/day), zinc sulfate (HE-Zn, 30 mg/kg/day), magnesium sulfate (HE-Mg, 50 mg/kg/d...

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Autores principales:	Ying Li, Chang Xue Ji, Li Hong Mei, Jin Wei Qiang, Shuai Ju
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1dc599cdca194171afcb3bcae0113549
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spelling	oai:doaj.org-article:1dc599cdca194171afcb3bcae01135492021-12-02T12:30:52ZOral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats10.1038/s41598-017-02101-82045-2322https://doaj.org/article/1dc599cdca194171afcb3bcae01135492017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02101-8https://doaj.org/toc/2045-2322Abstract The therapeutic effects of iron, zinc and magnesium trace elements, as well as rifaximin were investigated and compared in HE rats. In this study, HE rats were treated with either ferrous sulfate (HE-Fe, 30 mg/kg/day), zinc sulfate (HE-Zn, 30 mg/kg/day), magnesium sulfate (HE-Mg, 50 mg/kg/day) or rifaximin (HE-Rf, 50 mg/kg/day), which was mixed with water and administered orally for 61 days. The Morris water maze (MWM) and open-field tests were used to evaluate cognitive and locomotor function. The blood ammonia levels before and after administration of the glutamine challenge test, manganese concentration and glutamine synthetase (GS) activity were measured. Significantly longer MWM escape latencies, less locomotor activity, higher blood ammonia levels, higher brain manganese concentrations and higher GS activity were observed in HE rats. However, HE-Mg and HE-Rf rats had significantly shorter MWM escape latencies, increased locomotor activity, lower blood ammonia, lower brain manganese concentrations and lower GS activity. Partial improvements were observed in HE-Fe and HE-Zn rats. The results indicated that oral administration of magnesium can significantly improve the cognitive and locomotor functions in HE rats by reducing the brain manganese concentration and regulating GS activity.Ying LiChang Xue JiLi Hong MeiJin Wei QiangShuai JuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Li Chang Xue Ji Li Hong Mei Jin Wei Qiang Shuai Ju Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
description	Abstract The therapeutic effects of iron, zinc and magnesium trace elements, as well as rifaximin were investigated and compared in HE rats. In this study, HE rats were treated with either ferrous sulfate (HE-Fe, 30 mg/kg/day), zinc sulfate (HE-Zn, 30 mg/kg/day), magnesium sulfate (HE-Mg, 50 mg/kg/day) or rifaximin (HE-Rf, 50 mg/kg/day), which was mixed with water and administered orally for 61 days. The Morris water maze (MWM) and open-field tests were used to evaluate cognitive and locomotor function. The blood ammonia levels before and after administration of the glutamine challenge test, manganese concentration and glutamine synthetase (GS) activity were measured. Significantly longer MWM escape latencies, less locomotor activity, higher blood ammonia levels, higher brain manganese concentrations and higher GS activity were observed in HE rats. However, HE-Mg and HE-Rf rats had significantly shorter MWM escape latencies, increased locomotor activity, lower blood ammonia, lower brain manganese concentrations and lower GS activity. Partial improvements were observed in HE-Fe and HE-Zn rats. The results indicated that oral administration of magnesium can significantly improve the cognitive and locomotor functions in HE rats by reducing the brain manganese concentration and regulating GS activity.
format	article
author	Ying Li Chang Xue Ji Li Hong Mei Jin Wei Qiang Shuai Ju
author_facet	Ying Li Chang Xue Ji Li Hong Mei Jin Wei Qiang Shuai Ju
author_sort	Ying Li
title	Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
title_short	Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
title_full	Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
title_fullStr	Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
title_full_unstemmed	Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
title_sort	oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1dc599cdca194171afcb3bcae0113549
work_keys_str_mv	AT yingli oraladministrationoftraceelementmagnesiumsignificantlyimprovingthecognitionandlocomotioninhepaticencephalopathyrats AT changxueji oraladministrationoftraceelementmagnesiumsignificantlyimprovingthecognitionandlocomotioninhepaticencephalopathyrats AT lihongmei oraladministrationoftraceelementmagnesiumsignificantlyimprovingthecognitionandlocomotioninhepaticencephalopathyrats AT jinweiqiang oraladministrationoftraceelementmagnesiumsignificantlyimprovingthecognitionandlocomotioninhepaticencephalopathyrats AT shuaiju oraladministrationoftraceelementmagnesiumsignificantlyimprovingthecognitionandlocomotioninhepaticencephalopathyrats
_version_	1718394262720086016

Oral administration of trace element magnesium significantly improving the cognition and locomotion in hepatic encephalopathy rats

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