Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.

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Autores principales:	Pengfei Ma, Yujie Fu, Mei-Chun Cai, Ying Yan, Ying Jing, Shengzhe Zhang, Minjiang Chen, Jie Wu, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Wei-Qiang Gao, Mengzhao Wang, Zhenyu Gu, Trever G. Bivona, Xiaojing Zhao, Guanglei Zhuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1dc6dd11f0204afa83eef84ead94c50d
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spelling	oai:doaj.org-article:1dc6dd11f0204afa83eef84ead94c50d2021-12-02T17:01:19ZSimultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer10.1038/s41467-017-00963-02041-1723https://doaj.org/article/1dc6dd11f0204afa83eef84ead94c50d2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00963-0https://doaj.org/toc/2041-1723Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.Pengfei MaYujie FuMei-Chun CaiYing YanYing JingShengzhe ZhangMinjiang ChenJie WuYing ShenLiang ZhuHong-Zhuan ChenWei-Qiang GaoMengzhao WangZhenyu GuTrever G. BivonaXiaojing ZhaoGuanglei ZhuangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengfei Ma Yujie Fu Mei-Chun Cai Ying Yan Ying Jing Shengzhe Zhang Minjiang Chen Jie Wu Ying Shen Liang Zhu Hong-Zhuan Chen Wei-Qiang Gao Mengzhao Wang Zhenyu Gu Trever G. Bivona Xiaojing Zhao Guanglei Zhuang Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
description	Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.
format	article
author	Pengfei Ma Yujie Fu Mei-Chun Cai Ying Yan Ying Jing Shengzhe Zhang Minjiang Chen Jie Wu Ying Shen Liang Zhu Hong-Zhuan Chen Wei-Qiang Gao Mengzhao Wang Zhenyu Gu Trever G. Bivona Xiaojing Zhao Guanglei Zhuang
author_facet	Pengfei Ma Yujie Fu Mei-Chun Cai Ying Yan Ying Jing Shengzhe Zhang Minjiang Chen Jie Wu Ying Shen Liang Zhu Hong-Zhuan Chen Wei-Qiang Gao Mengzhao Wang Zhenyu Gu Trever G. Bivona Xiaojing Zhao Guanglei Zhuang
author_sort	Pengfei Ma
title	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
title_short	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
title_full	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
title_fullStr	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
title_full_unstemmed	Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
title_sort	simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1dc6dd11f0204afa83eef84ead94c50d
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Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

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