Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.

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Detalles Bibliográficos
Autores principales: Pengfei Ma, Yujie Fu, Mei-Chun Cai, Ying Yan, Ying Jing, Shengzhe Zhang, Minjiang Chen, Jie Wu, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Wei-Qiang Gao, Mengzhao Wang, Zhenyu Gu, Trever G. Bivona, Xiaojing Zhao, Guanglei Zhuang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/1dc6dd11f0204afa83eef84ead94c50d
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