Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach

Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated a mathematical model to better understand how...

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Autores principales:	Oriol Iborra-Egea, Carolina Gálvez-Montón, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Soler-Botija, Antoni Bayes-Genis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1dc9147ff92843cb906f2df012fb2dc5
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spelling	oai:doaj.org-article:1dc9147ff92843cb906f2df012fb2dc52021-12-02T12:33:54ZMechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach10.1038/s41540-017-0013-42056-7189https://doaj.org/article/1dc9147ff92843cb906f2df012fb2dc52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0013-4https://doaj.org/toc/2056-7189Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated a mathematical model to better understand how Sacubitril/Valsartan modulates pathological heart resize and the combined effect of the drug. Our analysis revealed that Sacubitril/Valsartan mainly acts by blocking both, cell death and the pathological makeover of the outer-membrane of the cardiac cells. These two major processes occur after a heart attack. Most importantly, we discovered a core of 8 proteins that emerge as key players in this process. A better understanding of the mechanism of novel cardiovascular drugs at the most basic level may help decipher future therapies and indications.Oriol Iborra-EgeaCarolina Gálvez-MontónSantiago RouraIsaac Perea-GilCristina Prat-VidalCarolina Soler-BotijaAntoni Bayes-GenisNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Oriol Iborra-Egea Carolina Gálvez-Montón Santiago Roura Isaac Perea-Gil Cristina Prat-Vidal Carolina Soler-Botija Antoni Bayes-Genis Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
description	Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated a mathematical model to better understand how Sacubitril/Valsartan modulates pathological heart resize and the combined effect of the drug. Our analysis revealed that Sacubitril/Valsartan mainly acts by blocking both, cell death and the pathological makeover of the outer-membrane of the cardiac cells. These two major processes occur after a heart attack. Most importantly, we discovered a core of 8 proteins that emerge as key players in this process. A better understanding of the mechanism of novel cardiovascular drugs at the most basic level may help decipher future therapies and indications.
format	article
author	Oriol Iborra-Egea Carolina Gálvez-Montón Santiago Roura Isaac Perea-Gil Cristina Prat-Vidal Carolina Soler-Botija Antoni Bayes-Genis
author_facet	Oriol Iborra-Egea Carolina Gálvez-Montón Santiago Roura Isaac Perea-Gil Cristina Prat-Vidal Carolina Soler-Botija Antoni Bayes-Genis
author_sort	Oriol Iborra-Egea
title	Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
title_short	Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
title_full	Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
title_fullStr	Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
title_full_unstemmed	Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
title_sort	mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1dc9147ff92843cb906f2df012fb2dc5
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Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach

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