Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS

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Autores principales:	Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gaber, Sung Yun Jung, Matthew L. Baker, Robia G. Pautler, Robert T. Dirksen, Sheila Riazi, Susan L. Hamilton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1dca01fbb1744c91925d570cd3ada4fa
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spelling	oai:doaj.org-article:1dca01fbb1744c91925d570cd3ada4fa2021-12-02T18:01:50ZAdaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation10.1038/s41467-020-18865-z2041-1723https://doaj.org/article/1dca01fbb1744c91925d570cd3ada4fa2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18865-zhttps://doaj.org/toc/2041-1723Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHSHui J. WangChang Seok LeeRachel Sue Zhen YeeLinda GroomInbar FriedmanLyle BabcockDimitra K. GeorgiouJin HongAmy D. HannaJoseph RecioJong Min ChoiTing ChangNadia H. AghaJonathan RomeroPoonam SarkarNicol VoermansM. Waleed GaberSung Yun JungMatthew L. BakerRobia G. PautlerRobert T. DirksenSheila RiaziSusan L. HamiltonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
description	Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS
format	article
author	Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton
author_facet	Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton
author_sort	Hui J. Wang
title	Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
title_short	Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
title_full	Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
title_fullStr	Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
title_full_unstemmed	Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
title_sort	adaptive thermogenesis enhances the life-threatening response to heat in mice with an ryr1 mutation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1dca01fbb1744c91925d570cd3ada4fa
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Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

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