DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted by antisense inhibitory oligonucleotides.

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Autores principales:	Francesca Rossiello, Julio Aguado, Sara Sepe, Fabio Iannelli, Quan Nguyen, Sethuramasundaram Pitchiaya, Piero Carninci, Fabrizio d’Adda di Fagagna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1dceda3e3a63458496e0b40a4c34adf3
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spelling	oai:doaj.org-article:1dceda3e3a63458496e0b40a4c34adf32021-12-02T14:42:20ZDNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs10.1038/ncomms139802041-1723https://doaj.org/article/1dceda3e3a63458496e0b40a4c34adf32017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms13980https://doaj.org/toc/2041-1723The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted by antisense inhibitory oligonucleotides.Francesca RossielloJulio AguadoSara SepeFabio IannelliQuan NguyenSethuramasundaram PitchiayaPiero CarninciFabrizio d’Adda di FagagnaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francesca Rossiello Julio Aguado Sara Sepe Fabio Iannelli Quan Nguyen Sethuramasundaram Pitchiaya Piero Carninci Fabrizio d’Adda di Fagagna DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
description	The DNA damage response (DDR) involves site-specific small non-coding RNAs. Here the authors show that telomere dysfunction induces transcription of telomeric DNA damage response RNAs that are necessary for DDR activation, which can be specifically muted by antisense inhibitory oligonucleotides.
format	article
author	Francesca Rossiello Julio Aguado Sara Sepe Fabio Iannelli Quan Nguyen Sethuramasundaram Pitchiaya Piero Carninci Fabrizio d’Adda di Fagagna
author_facet	Francesca Rossiello Julio Aguado Sara Sepe Fabio Iannelli Quan Nguyen Sethuramasundaram Pitchiaya Piero Carninci Fabrizio d’Adda di Fagagna
author_sort	Francesca Rossiello
title	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
title_short	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
title_full	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
title_fullStr	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
title_full_unstemmed	DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
title_sort	dna damage response inhibition at dysfunctional telomeres by modulation of telomeric dna damage response rnas
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1dceda3e3a63458496e0b40a4c34adf3
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DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

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