The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Abstract In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospit...

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Autores principales:	Chien-Hsiang Tai, Chien-Ning Hsu, Shih-Cheng Yang, Cheng-Kun Wu, Chih-Ming Liang, Wei-Chen Tai, Seng-Kee Chuah, Chen-Hsiang Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1dcf13f73c734e93804a509f2f9c35c6
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spelling	oai:doaj.org-article:1dcf13f73c734e93804a509f2f9c35c62021-12-02T12:34:16ZThe impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients10.1038/s41598-020-78442-82045-2322https://doaj.org/article/1dcf13f73c734e93804a509f2f9c35c62020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78442-8https://doaj.org/toc/2045-2322Abstract In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan–Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, p < 0.01), but not for that of IKPS (0.02% vs. 0.03%, p = 0.29). Patients taking aspirin for ≥ 90 days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50–0.90). Females, taking clopidogrel or metformin for ≥ 90 days, and taking H2-blockers or proton pump inhibitors (PPIs) for ≥ 5 days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin ≥ 8.5% were associated with an increased risk of KP-PLA.Chien-Hsiang TaiChien-Ning HsuShih-Cheng YangCheng-Kun WuChih-Ming LiangWei-Chen TaiSeng-Kee ChuahChen-Hsiang LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chien-Hsiang Tai Chien-Ning Hsu Shih-Cheng Yang Cheng-Kun Wu Chih-Ming Liang Wei-Chen Tai Seng-Kee Chuah Chen-Hsiang Lee The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
description	Abstract In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan–Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, p < 0.01), but not for that of IKPS (0.02% vs. 0.03%, p = 0.29). Patients taking aspirin for ≥ 90 days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50–0.90). Females, taking clopidogrel or metformin for ≥ 90 days, and taking H2-blockers or proton pump inhibitors (PPIs) for ≥ 5 days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin ≥ 8.5% were associated with an increased risk of KP-PLA.
format	article
author	Chien-Hsiang Tai Chien-Ning Hsu Shih-Cheng Yang Cheng-Kun Wu Chih-Ming Liang Wei-Chen Tai Seng-Kee Chuah Chen-Hsiang Lee
author_facet	Chien-Hsiang Tai Chien-Ning Hsu Shih-Cheng Yang Cheng-Kun Wu Chih-Ming Liang Wei-Chen Tai Seng-Kee Chuah Chen-Hsiang Lee
author_sort	Chien-Hsiang Tai
title	The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
title_short	The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
title_full	The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
title_fullStr	The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
title_full_unstemmed	The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients
title_sort	impact of aspirin on klebsiella pneumoniae liver abscess in diabetic patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1dcf13f73c734e93804a509f2f9c35c6
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The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

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