Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody

Shinji Ueno,1 Yasuki Ito,1 Ruka Maruko,1 Mineo Kondo,2 Hiroko Terasaki1 1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, 2Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan Abstract: The purpose of this paper is to report choroid...

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Autores principales:	Ueno S, Ito Y, Maruko R, Kondo M, Terasaki H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1dd0f598e39f40e1876169097958ca69
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spelling	oai:doaj.org-article:1dd0f598e39f40e1876169097958ca692021-12-02T03:05:51ZChoroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody1177-5483https://doaj.org/article/1dd0f598e39f40e1876169097958ca692014-02-01T00:00:00Zhttp://www.dovepress.com/choroidal-atrophy-in-a-patient-with-paraneoplastic-retinopathy-and-ant-a15721https://doaj.org/toc/1177-5483 Shinji Ueno,1 Yasuki Ito,1 Ruka Maruko,1 Mineo Kondo,2 Hiroko Terasaki1 1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, 2Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan Abstract: The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic in July 2010 with complaints of blurred vision and night blindness in both eyes. The full-field electroretinograms were negative type, indicating ON bipolar cell dysfunction. General physical examination revealed small cell carcinoma of the lung, and Western blot of the patient's serum showed autoantibodies against TRPM1. We diagnosed this patient with cancer-associated retinopathy and retinal ON bipolar dysfunction due to anti-TRPM1 autoantibody. We followed him for more than 2 years from the initial visit and his symptoms have not changed. However, consistent with the choroidal hypopigmentation of the fundus, spectral domain optical coherence tomography showed a decrease in choroidal thickness of about one third over a 2-year follow-up period. We suggest that this case of gradually progressive choroidal atrophy was caused by the autoantibody against TRPM1 directly, because TRPM1 is expressed not only on ON bipolar cells but also on melanocytes. These findings indicate that we should be aware of choroidal thickness in patients with paraneoplastic retinopathy who have retinal ON bipolar dysfunction with the anti-TRPM1 antibody. Keywords: choroidal thickness, melanocyte, TRPM1, cancer-associated retinopathy, paraneoplastic retinopathyUeno SIto YMaruko RKondo MTerasaki HDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 369-373 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Ueno S Ito Y Maruko R Kondo M Terasaki H Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
description	Shinji Ueno,1 Yasuki Ito,1 Ruka Maruko,1 Mineo Kondo,2 Hiroko Terasaki1 1Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, 2Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan Abstract: The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic in July 2010 with complaints of blurred vision and night blindness in both eyes. The full-field electroretinograms were negative type, indicating ON bipolar cell dysfunction. General physical examination revealed small cell carcinoma of the lung, and Western blot of the patient's serum showed autoantibodies against TRPM1. We diagnosed this patient with cancer-associated retinopathy and retinal ON bipolar dysfunction due to anti-TRPM1 autoantibody. We followed him for more than 2 years from the initial visit and his symptoms have not changed. However, consistent with the choroidal hypopigmentation of the fundus, spectral domain optical coherence tomography showed a decrease in choroidal thickness of about one third over a 2-year follow-up period. We suggest that this case of gradually progressive choroidal atrophy was caused by the autoantibody against TRPM1 directly, because TRPM1 is expressed not only on ON bipolar cells but also on melanocytes. These findings indicate that we should be aware of choroidal thickness in patients with paraneoplastic retinopathy who have retinal ON bipolar dysfunction with the anti-TRPM1 antibody. Keywords: choroidal thickness, melanocyte, TRPM1, cancer-associated retinopathy, paraneoplastic retinopathy
format	article
author	Ueno S Ito Y Maruko R Kondo M Terasaki H
author_facet	Ueno S Ito Y Maruko R Kondo M Terasaki H
author_sort	Ueno S
title	Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
title_short	Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
title_full	Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
title_fullStr	Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
title_full_unstemmed	Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody
title_sort	choroidal atrophy in a patient with paraneoplastic retinopathy and anti-trpm1 antibody
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/1dd0f598e39f40e1876169097958ca69
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Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody

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