Oxidative stress in hyperthermia
Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire th...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
Scientific Сentre for Family Health and Human Reproduction Problems
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1dd2dde9391147af9b88dd2095b3156f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire the ability to be rapidly accumulated in the cells of the vessel walls, causing pre-aterosklerotic lipoid damages. The aim of this study was to investigate the effect of high temperature (one of the environmental factors) for key operating parameters: the content of secondary products of free radical oxidation polyene lipids - mDa in blood plasma and erythrocyte antioxidant activity of key enzymes. Hyperthermia was triggered in practically healthy volunteers (6 males, 22-46years). The analysis was made using a recording spectrophotometer Hitachi-557 (Japan). The statistical analysis was performed using the non-parametric Wilcoxon-test (Attestat program). MDA levels in the blood plasma, the activity of key antioxidant enzymes in erythrocytes were determined through divided intervals in study participants. A significant increase in MDA content (62 %) and reduction of catalase activity (11 %) and glutathione peroxidase (19 %) were revealed after 30 days in the conditions of hyperthermia test. |
|---|