Oxidative stress in hyperthermia

Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire th...

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Autores principales:	M. K. Osyaeva, A. K. Tikhaze, V. Z. Lankin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	reactive oxygen species free radical oxidation malondialdehyde catalase glutathione peroxidase Science Q
Acceso en línea:	https://doaj.org/article/1dd2dde9391147af9b88dd2095b3156f
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spelling	oai:doaj.org-article:1dd2dde9391147af9b88dd2095b3156f2021-11-23T06:14:34ZOxidative stress in hyperthermia2541-94202587-959610.12737/article_590823a4f0d734.72519988https://doaj.org/article/1dd2dde9391147af9b88dd2095b3156f2016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/203https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire the ability to be rapidly accumulated in the cells of the vessel walls, causing pre-aterosklerotic lipoid damages. The aim of this study was to investigate the effect of high temperature (one of the environmental factors) for key operating parameters: the content of secondary products of free radical oxidation polyene lipids - mDa in blood plasma and erythrocyte antioxidant activity of key enzymes. Hyperthermia was triggered in practically healthy volunteers (6 males, 22-46years). The analysis was made using a recording spectrophotometer Hitachi-557 (Japan). The statistical analysis was performed using the non-parametric Wilcoxon-test (Attestat program). MDA levels in the blood plasma, the activity of key antioxidant enzymes in erythrocytes were determined through divided intervals in study participants. A significant increase in MDA content (62 %) and reduction of catalase activity (11 %) and glutathione peroxidase (19 %) were revealed after 30 days in the conditions of hyperthermia test.M. K. OsyaevaA. K. TikhazeV. Z. LankinScientific Сentre for Family Health and Human Reproduction Problemsarticlereactive oxygen speciesfree radical oxidationmalondialdehydecatalaseglutathione peroxidaseScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 124-127 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	reactive oxygen species free radical oxidation malondialdehyde catalase glutathione peroxidase Science Q
spellingShingle	reactive oxygen species free radical oxidation malondialdehyde catalase glutathione peroxidase Science Q M. K. Osyaeva A. K. Tikhaze V. Z. Lankin Oxidative stress in hyperthermia
description	Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire the ability to be rapidly accumulated in the cells of the vessel walls, causing pre-aterosklerotic lipoid damages. The aim of this study was to investigate the effect of high temperature (one of the environmental factors) for key operating parameters: the content of secondary products of free radical oxidation polyene lipids - mDa in blood plasma and erythrocyte antioxidant activity of key enzymes. Hyperthermia was triggered in practically healthy volunteers (6 males, 22-46years). The analysis was made using a recording spectrophotometer Hitachi-557 (Japan). The statistical analysis was performed using the non-parametric Wilcoxon-test (Attestat program). MDA levels in the blood plasma, the activity of key antioxidant enzymes in erythrocytes were determined through divided intervals in study participants. A significant increase in MDA content (62 %) and reduction of catalase activity (11 %) and glutathione peroxidase (19 %) were revealed after 30 days in the conditions of hyperthermia test.
format	article
author	M. K. Osyaeva A. K. Tikhaze V. Z. Lankin
author_facet	M. K. Osyaeva A. K. Tikhaze V. Z. Lankin
author_sort	M. K. Osyaeva
title	Oxidative stress in hyperthermia
title_short	Oxidative stress in hyperthermia
title_full	Oxidative stress in hyperthermia
title_fullStr	Oxidative stress in hyperthermia
title_full_unstemmed	Oxidative stress in hyperthermia
title_sort	oxidative stress in hyperthermia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/1dd2dde9391147af9b88dd2095b3156f
work_keys_str_mv	AT mkosyaeva oxidativestressinhyperthermia AT aktikhaze oxidativestressinhyperthermia AT vzlankin oxidativestressinhyperthermia
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Oxidative stress in hyperthermia

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