A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.

<h4>Background</h4>In general, immune effector molecules are induced by infection.<h4>Methodology and principal findings</h4>However, strong constitutive expression of the cell-autonomous resistance GTPase, Irga6 (IIGP1), was found in mouse liver, contrasting with previous ev...

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Autores principales:	Jia Zeng, Iana Angelova Parvanova, Jonathan C Howard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ddea200e7ab48d68320de0a70aa4148
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spelling	oai:doaj.org-article:1ddea200e7ab48d68320de0a70aa41482021-11-25T06:28:50ZA dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.1932-620310.1371/journal.pone.0006787https://doaj.org/article/1ddea200e7ab48d68320de0a70aa41482009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20368812/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In general, immune effector molecules are induced by infection.<h4>Methodology and principal findings</h4>However, strong constitutive expression of the cell-autonomous resistance GTPase, Irga6 (IIGP1), was found in mouse liver, contrasting with previous evidence that expression of this protein is exclusively dependent on induction by IFNgamma. Constitutive and IFNgamma-inducible expression of Irga6 in the liver were shown to be dependent on transcription initiated from two independent untranslated 5' exons, which splice alternatively into the long exon encoding the full-length protein sequence. Irga6 is expressed constitutively in freshly isolated hepatocytes and is competent in these cells to accumulate on the parasitophorous vacuole membrane of infecting Toxoplasma gondii tachyzoites.<h4>Conclusions and significance</h4>The role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system is discussed.Jia ZengIana Angelova ParvanovaJonathan C HowardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6787 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia Zeng Iana Angelova Parvanova Jonathan C Howard A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
description	<h4>Background</h4>In general, immune effector molecules are induced by infection.<h4>Methodology and principal findings</h4>However, strong constitutive expression of the cell-autonomous resistance GTPase, Irga6 (IIGP1), was found in mouse liver, contrasting with previous evidence that expression of this protein is exclusively dependent on induction by IFNgamma. Constitutive and IFNgamma-inducible expression of Irga6 in the liver were shown to be dependent on transcription initiated from two independent untranslated 5' exons, which splice alternatively into the long exon encoding the full-length protein sequence. Irga6 is expressed constitutively in freshly isolated hepatocytes and is competent in these cells to accumulate on the parasitophorous vacuole membrane of infecting Toxoplasma gondii tachyzoites.<h4>Conclusions and significance</h4>The role of constitutive hepatocyte expression of Irga6 in resistance to parasites invading from the gut via the hepatic portal system is discussed.
format	article
author	Jia Zeng Iana Angelova Parvanova Jonathan C Howard
author_facet	Jia Zeng Iana Angelova Parvanova Jonathan C Howard
author_sort	Jia Zeng
title	A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
title_short	A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
title_full	A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
title_fullStr	A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
title_full_unstemmed	A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.
title_sort	dedicated promoter drives constitutive expression of the cell-autonomous immune resistance gtpase, irga6 (iigp1) in mouse liver.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/1ddea200e7ab48d68320de0a70aa4148
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A dedicated promoter drives constitutive expression of the cell-autonomous immune resistance GTPase, Irga6 (IIGP1) in mouse liver.

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