Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age
Abstract Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the survival of younger and older patients in stage II/III rectal cancer. Data was obtained f...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1ddf80997ec4434489697a9d9874ea90 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1ddf80997ec4434489697a9d9874ea90 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1ddf80997ec4434489697a9d9874ea902021-12-02T15:05:37ZPopulation-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age10.1038/s41598-017-02992-72045-2322https://doaj.org/article/1ddf80997ec4434489697a9d9874ea902017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02992-7https://doaj.org/toc/2045-2322Abstract Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the survival of younger and older patients in stage II/III rectal cancer. Data was obtained from Surveillance, Epidemiology, and End Results (SEER) database (n = 12801). Propensity score matching was used to balance baseline covariates according to the status of neoadjuvant radiation. Our results showed that neoadjuvant radiation had better survival benefit (Log-rank P = 3.25e-06) and improved cancer-specific 3-year (87.6%; 95% CI: 86.4–88.7% vs. 84.1%; 95% CI: 82.8–85.3%) and 5-year survival rates (78.1%; 95% CI: 76.2–80.1% vs. 77%; 95% CI: 75.3–78.8%). In older groups (>50), neoadjuvant radiation was associated with survival benefits in stage II (HR: 0.741; 95% CI: 0.599–0.916; P = 5.80e-3) and stage III (HR: 0.656; 95% CI 0.564–0.764; P = 5.26e-08). Interestingly, neoadjuvant radiation did not increase survival rate in younger patients (< = 50) both in stage II (HR: 2.014; 95% CI: 0.9032–4.490; P = 0.087) and stage III (HR: 1.168; 95% CI: 0.829–1.646; P = 0.372). Additionally, neoadjuvant radiation significantly decreased the cancer-specific mortality in older patients, but increased mortality in younger patients. Our results provided new insights on the neoadjuvant radiation in rectal cancer, especially for the younger patients.Leilei WuShichao PangQianlan YaoChen JianPing LinFangyoumin FengHong LiYixue LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Leilei Wu Shichao Pang Qianlan Yao Chen Jian Ping Lin Fangyoumin Feng Hong Li Yixue Li Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| description |
Abstract Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the survival of younger and older patients in stage II/III rectal cancer. Data was obtained from Surveillance, Epidemiology, and End Results (SEER) database (n = 12801). Propensity score matching was used to balance baseline covariates according to the status of neoadjuvant radiation. Our results showed that neoadjuvant radiation had better survival benefit (Log-rank P = 3.25e-06) and improved cancer-specific 3-year (87.6%; 95% CI: 86.4–88.7% vs. 84.1%; 95% CI: 82.8–85.3%) and 5-year survival rates (78.1%; 95% CI: 76.2–80.1% vs. 77%; 95% CI: 75.3–78.8%). In older groups (>50), neoadjuvant radiation was associated with survival benefits in stage II (HR: 0.741; 95% CI: 0.599–0.916; P = 5.80e-3) and stage III (HR: 0.656; 95% CI 0.564–0.764; P = 5.26e-08). Interestingly, neoadjuvant radiation did not increase survival rate in younger patients (< = 50) both in stage II (HR: 2.014; 95% CI: 0.9032–4.490; P = 0.087) and stage III (HR: 1.168; 95% CI: 0.829–1.646; P = 0.372). Additionally, neoadjuvant radiation significantly decreased the cancer-specific mortality in older patients, but increased mortality in younger patients. Our results provided new insights on the neoadjuvant radiation in rectal cancer, especially for the younger patients. |
| format |
article |
| author |
Leilei Wu Shichao Pang Qianlan Yao Chen Jian Ping Lin Fangyoumin Feng Hong Li Yixue Li |
| author_facet |
Leilei Wu Shichao Pang Qianlan Yao Chen Jian Ping Lin Fangyoumin Feng Hong Li Yixue Li |
| author_sort |
Leilei Wu |
| title |
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| title_short |
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| title_full |
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| title_fullStr |
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| title_full_unstemmed |
Population-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age |
| title_sort |
population-based study of effectiveness of neoadjuvant radiotherapy on survival in us rectal cancer patients according to age |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1ddf80997ec4434489697a9d9874ea90 |
| work_keys_str_mv |
AT leileiwu populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT shichaopang populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT qianlanyao populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT chenjian populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT pinglin populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT fangyouminfeng populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT hongli populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage AT yixueli populationbasedstudyofeffectivenessofneoadjuvantradiotherapyonsurvivalinusrectalcancerpatientsaccordingtoage |
| _version_ |
1718388752965959680 |