Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival

Abstract Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From J...

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Autores principales:	Jungchan Park, Seung-Hwa Lee, Mi Sook Gwak, Justin Sangwook Ko, Sangbin Han, Gyu-Seong Choi, Jae Won Joh, Jongman Kim, Gaab Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1de01761458a4b8cb655719d524e71ca
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spelling	oai:doaj.org-article:1de01761458a4b8cb655719d524e71ca2021-12-02T14:03:46ZAssociation between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival10.1038/s41598-021-83814-92045-2322https://doaj.org/article/1de01761458a4b8cb655719d524e71ca2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83814-9https://doaj.org/toc/2045-2322Abstract Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From June 1997 to April 2019, we identified 1292 adult LDLT recipients with intraoperative NLR change. The recipients were divided according to NLR change: 103 (8.0%) in the decrease group and 1189 (92.0%) in the increase group. The primary outcome was graft failure in the first year. In addition, variables associated with NLR change during LDLT were evaluated. During 1-year follow-up, graft failure was significantly higher in the decrease group (22.3% vs. 9.1%; hazard ratio 1.87; 95% confidence interval 1.10–3.18; p = 0.02), but postoperative complications did not differ between two groups. This finding was consistent for the overall follow-up. Variables associated with NLR decrease included preoperative NLR > 4, model for end-stage liver disease score, intraoperative inotropic infusion and red blood cell transfusion, and operative duration. The least absolute shrinkage and selection operator model yielded similar results. NLR decrease during LDLT appeared to be independently associated with graft survival. Further studies are needed to confirm our findings.Jungchan ParkSeung-Hwa LeeMi Sook GwakJustin Sangwook KoSangbin HanGyu-Seong ChoiJae Won JohJongman KimGaab Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jungchan Park Seung-Hwa Lee Mi Sook Gwak Justin Sangwook Ko Sangbin Han Gyu-Seong Choi Jae Won Joh Jongman Kim Gaab Soo Kim Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
description	Abstract Preoperative neutrophil–lymphocyte ratio (NLR), has shown a predictive value in living donor liver transplantation (LDLT). However, the change in the NLR during LDLT has not been fully investigated. We aimed to compare graft survival between the NLR increase and decrease during LDLT. From June 1997 to April 2019, we identified 1292 adult LDLT recipients with intraoperative NLR change. The recipients were divided according to NLR change: 103 (8.0%) in the decrease group and 1189 (92.0%) in the increase group. The primary outcome was graft failure in the first year. In addition, variables associated with NLR change during LDLT were evaluated. During 1-year follow-up, graft failure was significantly higher in the decrease group (22.3% vs. 9.1%; hazard ratio 1.87; 95% confidence interval 1.10–3.18; p = 0.02), but postoperative complications did not differ between two groups. This finding was consistent for the overall follow-up. Variables associated with NLR decrease included preoperative NLR > 4, model for end-stage liver disease score, intraoperative inotropic infusion and red blood cell transfusion, and operative duration. The least absolute shrinkage and selection operator model yielded similar results. NLR decrease during LDLT appeared to be independently associated with graft survival. Further studies are needed to confirm our findings.
format	article
author	Jungchan Park Seung-Hwa Lee Mi Sook Gwak Justin Sangwook Ko Sangbin Han Gyu-Seong Choi Jae Won Joh Jongman Kim Gaab Soo Kim
author_facet	Jungchan Park Seung-Hwa Lee Mi Sook Gwak Justin Sangwook Ko Sangbin Han Gyu-Seong Choi Jae Won Joh Jongman Kim Gaab Soo Kim
author_sort	Jungchan Park
title	Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_short	Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_full	Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_fullStr	Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_full_unstemmed	Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
title_sort	association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1de01761458a4b8cb655719d524e71ca
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Association between neutrophil–lymphocyte ratio change during living donor liver transplantation and graft survival

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