COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS

The purpose of this work was to evaluate the information obtained using some digital techniques for measuring the external form of pharmaceutical solids, employing a combination of several contour descriptors by means of classical and mathematics descriptors and a modified method of texture analysis...

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Autores principales:	Oscar FLÓREZ Ph.D., Gloria E. TOBÓN Z. Ph.D., Jaime A. VALENCIA V. Ph.D.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2012
Materias:	Descriptors texture crystallization phenytoin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/1de1f4d8d8f24ae38c9280b91a1e89f4
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spelling	oai:doaj.org-article:1de1f4d8d8f24ae38c9280b91a1e89f42021-11-19T04:12:51ZCOMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS0121-40042145-2660https://doaj.org/article/1de1f4d8d8f24ae38c9280b91a1e89f42012-09-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/10828https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The purpose of this work was to evaluate the information obtained using some digital techniques for measuring the external form of pharmaceutical solids, employing a combination of several contour descriptors by means of classical and mathematics descriptors and a modified method of texture analysis technique based on Gray levels co-occurrence matrix. In this case, phenytoin was used as a model, because changing some conditions in the recrystallization process different crystalline habits were obtained. The evaluations of the measurements were performed using techniques of principal component analysis and hierarchical cluster analysis. Final analysis indicated that applying the texture technique Gray levels co-occurrence matrix measurement, the results were similar to those obtained by combining contour measurement with classical and mathematics descriptors techniques, therefore, as the texture method is faster and easier to implement, could be a good alternative for use in quality control of multisource pharmaceutical solid.Oscar FLÓREZ Ph.D.Gloria E. TOBÓN Z. Ph.D.Jaime A. VALENCIA V. Ph.D.Universidad de AntioquiaarticleDescriptorstexturecrystallizationphenytoinFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 19, Iss 2 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Descriptors texture crystallization phenytoin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Descriptors texture crystallization phenytoin Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Oscar FLÓREZ Ph.D. Gloria E. TOBÓN Z. Ph.D. Jaime A. VALENCIA V. Ph.D. COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
description	The purpose of this work was to evaluate the information obtained using some digital techniques for measuring the external form of pharmaceutical solids, employing a combination of several contour descriptors by means of classical and mathematics descriptors and a modified method of texture analysis technique based on Gray levels co-occurrence matrix. In this case, phenytoin was used as a model, because changing some conditions in the recrystallization process different crystalline habits were obtained. The evaluations of the measurements were performed using techniques of principal component analysis and hierarchical cluster analysis. Final analysis indicated that applying the texture technique Gray levels co-occurrence matrix measurement, the results were similar to those obtained by combining contour measurement with classical and mathematics descriptors techniques, therefore, as the texture method is faster and easier to implement, could be a good alternative for use in quality control of multisource pharmaceutical solid.
format	article
author	Oscar FLÓREZ Ph.D. Gloria E. TOBÓN Z. Ph.D. Jaime A. VALENCIA V. Ph.D.
author_facet	Oscar FLÓREZ Ph.D. Gloria E. TOBÓN Z. Ph.D. Jaime A. VALENCIA V. Ph.D.
author_sort	Oscar FLÓREZ Ph.D.
title	COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
title_short	COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
title_full	COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
title_fullStr	COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
title_full_unstemmed	COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS
title_sort	comparative digital analysis of different phenytoin crystal habits
publisher	Universidad de Antioquia
publishDate	2012
url	https://doaj.org/article/1de1f4d8d8f24ae38c9280b91a1e89f4
work_keys_str_mv	AT oscarflorezphd comparativedigitalanalysisofdifferentphenytoincrystalhabits AT gloriaetobonzphd comparativedigitalanalysisofdifferentphenytoincrystalhabits AT jaimeavalenciavphd comparativedigitalanalysisofdifferentphenytoincrystalhabits
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COMPARATIVE DIGITAL ANALYSIS OF DIFFERENT PHENYTOIN CRYSTAL HABITS

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