Microbiota-based markers predictive of development of Clostridioides difficile infection

Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patient...

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Autores principales:	Matilda Berkell, Mohamed Mysara, Basil Britto Xavier, Cornelis H. van Werkhoven, Pieter Monsieurs, Christine Lammens, Annie Ducher, Maria J. G. T. Vehreschild, Herman Goossens, Jean de Gunzburg, Marc J. M. Bonten, Surbhi Malhotra-Kumar, the ANTICIPATE study group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1de252e145b94e59bca39bdbc0ab7fb7
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spelling	oai:doaj.org-article:1de252e145b94e59bca39bdbc0ab7fb72021-12-02T14:25:16ZMicrobiota-based markers predictive of development of Clostridioides difficile infection10.1038/s41467-021-22302-02041-1723https://doaj.org/article/1de252e145b94e59bca39bdbc0ab7fb72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22302-0https://doaj.org/toc/2041-1723Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.Matilda BerkellMohamed MysaraBasil Britto XavierCornelis H. van WerkhovenPieter MonsieursChristine LammensAnnie DucherMaria J. G. T. VehreschildHerman GoossensJean de GunzburgMarc J. M. BontenSurbhi Malhotra-Kumarthe ANTICIPATE study groupNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matilda Berkell Mohamed Mysara Basil Britto Xavier Cornelis H. van Werkhoven Pieter Monsieurs Christine Lammens Annie Ducher Maria J. G. T. Vehreschild Herman Goossens Jean de Gunzburg Marc J. M. Bonten Surbhi Malhotra-Kumar the ANTICIPATE study group Microbiota-based markers predictive of development of Clostridioides difficile infection
description	Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.
format	article
author	Matilda Berkell Mohamed Mysara Basil Britto Xavier Cornelis H. van Werkhoven Pieter Monsieurs Christine Lammens Annie Ducher Maria J. G. T. Vehreschild Herman Goossens Jean de Gunzburg Marc J. M. Bonten Surbhi Malhotra-Kumar the ANTICIPATE study group
author_facet	Matilda Berkell Mohamed Mysara Basil Britto Xavier Cornelis H. van Werkhoven Pieter Monsieurs Christine Lammens Annie Ducher Maria J. G. T. Vehreschild Herman Goossens Jean de Gunzburg Marc J. M. Bonten Surbhi Malhotra-Kumar the ANTICIPATE study group
author_sort	Matilda Berkell
title	Microbiota-based markers predictive of development of Clostridioides difficile infection
title_short	Microbiota-based markers predictive of development of Clostridioides difficile infection
title_full	Microbiota-based markers predictive of development of Clostridioides difficile infection
title_fullStr	Microbiota-based markers predictive of development of Clostridioides difficile infection
title_full_unstemmed	Microbiota-based markers predictive of development of Clostridioides difficile infection
title_sort	microbiota-based markers predictive of development of clostridioides difficile infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1de252e145b94e59bca39bdbc0ab7fb7
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Microbiota-based markers predictive of development of Clostridioides difficile infection

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