In-vivo X-ray Dark-Field Chest Radiography of a Pig

Abstract X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lukas B. Gromann, Fabio De Marco, Konstantin Willer, Peter B. Noël, Kai Scherer, Bernhard Renger, Bernhard Gleich, Klaus Achterhold, Alexander A. Fingerle, Daniela Muenzel, Sigrid Auweter, Katharina Hellbach, Maximilian Reiser, Andrea Baehr, Michaela Dmochewitz, Tobias J. Schroeter, Frieder J. Koch, Pascal Meyer, Danays Kunka, Juergen Mohr, Andre Yaroshenko, Hanns-Ingo Maack, Thomas Pralow, Hendrik van der Heijden, Roland Proksa, Thomas Koehler, Nataly Wieberneit, Karsten Rindt, Ernst J. Rummeny, Franz Pfeiffer, Julia Herzen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1de4408a643a41139cca13bd93d9eadf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1de4408a643a41139cca13bd93d9eadf
record_format	dspace
spelling	oai:doaj.org-article:1de4408a643a41139cca13bd93d9eadf2021-12-02T11:50:57ZIn-vivo X-ray Dark-Field Chest Radiography of a Pig10.1038/s41598-017-05101-w2045-2322https://doaj.org/article/1de4408a643a41139cca13bd93d9eadf2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05101-whttps://doaj.org/toc/2045-2322Abstract X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.Lukas B. GromannFabio De MarcoKonstantin WillerPeter B. NoëlKai SchererBernhard RengerBernhard GleichKlaus AchterholdAlexander A. FingerleDaniela MuenzelSigrid AuweterKatharina HellbachMaximilian ReiserAndrea BaehrMichaela DmochewitzTobias J. SchroeterFrieder J. KochPascal MeyerDanays KunkaJuergen MohrAndre YaroshenkoHanns-Ingo MaackThomas PralowHendrik van der HeijdenRoland ProksaThomas KoehlerNataly WieberneitKarsten RindtErnst J. RummenyFranz PfeifferJulia HerzenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lukas B. Gromann Fabio De Marco Konstantin Willer Peter B. Noël Kai Scherer Bernhard Renger Bernhard Gleich Klaus Achterhold Alexander A. Fingerle Daniela Muenzel Sigrid Auweter Katharina Hellbach Maximilian Reiser Andrea Baehr Michaela Dmochewitz Tobias J. Schroeter Frieder J. Koch Pascal Meyer Danays Kunka Juergen Mohr Andre Yaroshenko Hanns-Ingo Maack Thomas Pralow Hendrik van der Heijden Roland Proksa Thomas Koehler Nataly Wieberneit Karsten Rindt Ernst J. Rummeny Franz Pfeiffer Julia Herzen In-vivo X-ray Dark-Field Chest Radiography of a Pig
description	Abstract X-ray chest radiography is an inexpensive and broadly available tool for initial assessment of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of pulmonary diseases in their early stages. Recent X-ray dark-field (XDF) imaging studies on mice have shown significant improvements in imaging-based lung diagnostics. Especially in the case of early diagnosis of chronic obstructive pulmonary disease (COPD), XDF imaging clearly outperforms conventional radiography. However, a translation of this technique towards the investigation of larger mammals and finally humans has not yet been achieved. In this letter, we present the first in-vivo XDF full-field chest radiographs (32 × 35 cm2) of a living pig, acquired with clinically compatible parameters (40 s scan time, approx. 80 µSv dose). For imaging, we developed a novel high-energy XDF system that overcomes the limitations of currently established setups. Our XDF radiographs yield sufficiently high image quality to enable radiographic evaluation of the lungs. We consider this a milestone in the bench-to-bedside translation of XDF imaging and expect XDF imaging to become an invaluable tool in clinical practice, both as a general chest X-ray modality and as a dedicated tool for high-risk patients affected by smoking, industrial work and indoor cooking.
format	article
author	Lukas B. Gromann Fabio De Marco Konstantin Willer Peter B. Noël Kai Scherer Bernhard Renger Bernhard Gleich Klaus Achterhold Alexander A. Fingerle Daniela Muenzel Sigrid Auweter Katharina Hellbach Maximilian Reiser Andrea Baehr Michaela Dmochewitz Tobias J. Schroeter Frieder J. Koch Pascal Meyer Danays Kunka Juergen Mohr Andre Yaroshenko Hanns-Ingo Maack Thomas Pralow Hendrik van der Heijden Roland Proksa Thomas Koehler Nataly Wieberneit Karsten Rindt Ernst J. Rummeny Franz Pfeiffer Julia Herzen
author_facet	Lukas B. Gromann Fabio De Marco Konstantin Willer Peter B. Noël Kai Scherer Bernhard Renger Bernhard Gleich Klaus Achterhold Alexander A. Fingerle Daniela Muenzel Sigrid Auweter Katharina Hellbach Maximilian Reiser Andrea Baehr Michaela Dmochewitz Tobias J. Schroeter Frieder J. Koch Pascal Meyer Danays Kunka Juergen Mohr Andre Yaroshenko Hanns-Ingo Maack Thomas Pralow Hendrik van der Heijden Roland Proksa Thomas Koehler Nataly Wieberneit Karsten Rindt Ernst J. Rummeny Franz Pfeiffer Julia Herzen
author_sort	Lukas B. Gromann
title	In-vivo X-ray Dark-Field Chest Radiography of a Pig
title_short	In-vivo X-ray Dark-Field Chest Radiography of a Pig
title_full	In-vivo X-ray Dark-Field Chest Radiography of a Pig
title_fullStr	In-vivo X-ray Dark-Field Chest Radiography of a Pig
title_full_unstemmed	In-vivo X-ray Dark-Field Chest Radiography of a Pig
title_sort	in-vivo x-ray dark-field chest radiography of a pig
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1de4408a643a41139cca13bd93d9eadf
work_keys_str_mv	AT lukasbgromann invivoxraydarkfieldchestradiographyofapig AT fabiodemarco invivoxraydarkfieldchestradiographyofapig AT konstantinwiller invivoxraydarkfieldchestradiographyofapig AT peterbnoel invivoxraydarkfieldchestradiographyofapig AT kaischerer invivoxraydarkfieldchestradiographyofapig AT bernhardrenger invivoxraydarkfieldchestradiographyofapig AT bernhardgleich invivoxraydarkfieldchestradiographyofapig AT klausachterhold invivoxraydarkfieldchestradiographyofapig AT alexanderafingerle invivoxraydarkfieldchestradiographyofapig AT danielamuenzel invivoxraydarkfieldchestradiographyofapig AT sigridauweter invivoxraydarkfieldchestradiographyofapig AT katharinahellbach invivoxraydarkfieldchestradiographyofapig AT maximilianreiser invivoxraydarkfieldchestradiographyofapig AT andreabaehr invivoxraydarkfieldchestradiographyofapig AT michaeladmochewitz invivoxraydarkfieldchestradiographyofapig AT tobiasjschroeter invivoxraydarkfieldchestradiographyofapig AT friederjkoch invivoxraydarkfieldchestradiographyofapig AT pascalmeyer invivoxraydarkfieldchestradiographyofapig AT danayskunka invivoxraydarkfieldchestradiographyofapig AT juergenmohr invivoxraydarkfieldchestradiographyofapig AT andreyaroshenko invivoxraydarkfieldchestradiographyofapig AT hannsingomaack invivoxraydarkfieldchestradiographyofapig AT thomaspralow invivoxraydarkfieldchestradiographyofapig AT hendrikvanderheijden invivoxraydarkfieldchestradiographyofapig AT rolandproksa invivoxraydarkfieldchestradiographyofapig AT thomaskoehler invivoxraydarkfieldchestradiographyofapig AT natalywieberneit invivoxraydarkfieldchestradiographyofapig AT karstenrindt invivoxraydarkfieldchestradiographyofapig AT ernstjrummeny invivoxraydarkfieldchestradiographyofapig AT franzpfeiffer invivoxraydarkfieldchestradiographyofapig AT juliaherzen invivoxraydarkfieldchestradiographyofapig
_version_	1718395151407120384

In-vivo X-ray Dark-Field Chest Radiography of a Pig

Ejemplares similares