The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/1de87b299b0044dc8a38c75fa107c015 |
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oai:doaj.org-article:1de87b299b0044dc8a38c75fa107c0152021-12-02T16:49:25ZThe Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation10.1038/ncomms131982041-1723https://doaj.org/article/1de87b299b0044dc8a38c75fa107c0152016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13198https://doaj.org/toc/2041-1723Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.Kwok Ho YipNatasha KolesnikoffNicholas HauschildLisa BiggsAngel F. LopezStephen J. GalliSharad KumarMichele A. GrimbaldestonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| description |
Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation. |
| format |
article |
| author |
Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston |
| author_facet |
Kwok Ho Yip Natasha Kolesnikoff Nicholas Hauschild Lisa Biggs Angel F. Lopez Stephen J. Galli Sharad Kumar Michele A. Grimbaldeston |
| author_sort |
Kwok Ho Yip |
| title |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_short |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_full |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_fullStr |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_full_unstemmed |
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation |
| title_sort |
nedd4-2/ndfip1 axis is a negative regulator of ige-mediated mast cell activation |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1de87b299b0044dc8a38c75fa107c015 |
| work_keys_str_mv |
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1718383321414631424 |