Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets

The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either wa...

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Autores principales:	Xin-Dong Xiang, Zhang-Chao Deng, You-Wei Wang, Hua Sun, Li Wang, Yan-Ming Han, Yuan-Yuan Wu, Jian-Gao Liu, Lv-Hui Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	weanling pigs acidifiers performance redox status immunity gut microbiota Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/1def00f2188a49d1bc09237d632e68d4
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spelling	oai:doaj.org-article:1def00f2188a49d1bc09237d632e68d42021-11-25T16:25:38ZOrganic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets10.3390/antiox101116652076-3921https://doaj.org/article/1def00f2188a49d1bc09237d632e68d42021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1665https://doaj.org/toc/2076-3921The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either water (control) or water plus 2.0 L/Ton organic acid (OA) blends, such as OA1 or OA2, respectively, for 7 weeks. Compared to the control, OA1 and OA2 improved growth performance and/or reduced the piglets’ diarrhea rate during the various periods and improved small intestinal morphology at days 14 and/or 49. OA1 and OA2 also increased serum CAT and SOD activities and/or T-AOC and, as expected, decreased MDA concentration. Moreover, at day 14 and/or day 49, OA1 and OA2 increased the jejunal mRNA levels of host defense peptides (<i>PBD1</i>, <i>PBD2</i>, <i>NPG1,</i> and <i>NPG3</i>) and tight junction genes (claudin-1) and decreased that of cytokines (<i>IL-1β</i> and <i>IL-2</i>). Additionally, the two acidifiers regulated the abundance of several cecum bacterial genera, including <i>Blautia</i>, <i>Bulleidia</i>, <i>Coprococcus</i>, <i>Dorea</i>, <i>Eubacterium</i>, <i>Subdoligranulum,</i> and <i>YRC2</i>. In conclusion, both of the organic acid blends improved piglet growth performance and health status, potentially by regulating intestinal redox homeostasis, immunity, and microflora.Xin-Dong XiangZhang-Chao DengYou-Wei WangHua SunLi WangYan-Ming HanYuan-Yuan WuJian-Gao LiuLv-Hui SunMDPI AGarticleweanling pigsacidifiersperformanceredox statusimmunitygut microbiotaTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1665, p 1665 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	weanling pigs acidifiers performance redox status immunity gut microbiota Therapeutics. Pharmacology RM1-950
spellingShingle	weanling pigs acidifiers performance redox status immunity gut microbiota Therapeutics. Pharmacology RM1-950 Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
description	The objective of this study is to evaluate the effects of organic acids on piglet growth performance and health status. A total of 360 weanling pigs (5.3 ± 0.6 kg) were randomly allotted to 3 treatment groups with 12 replicates of 10 pigs/pen. Piglets were fed the same basal diet and given either water (control) or water plus 2.0 L/Ton organic acid (OA) blends, such as OA1 or OA2, respectively, for 7 weeks. Compared to the control, OA1 and OA2 improved growth performance and/or reduced the piglets’ diarrhea rate during the various periods and improved small intestinal morphology at days 14 and/or 49. OA1 and OA2 also increased serum CAT and SOD activities and/or T-AOC and, as expected, decreased MDA concentration. Moreover, at day 14 and/or day 49, OA1 and OA2 increased the jejunal mRNA levels of host defense peptides (<i>PBD1</i>, <i>PBD2</i>, <i>NPG1,</i> and <i>NPG3</i>) and tight junction genes (claudin-1) and decreased that of cytokines (<i>IL-1β</i> and <i>IL-2</i>). Additionally, the two acidifiers regulated the abundance of several cecum bacterial genera, including <i>Blautia</i>, <i>Bulleidia</i>, <i>Coprococcus</i>, <i>Dorea</i>, <i>Eubacterium</i>, <i>Subdoligranulum,</i> and <i>YRC2</i>. In conclusion, both of the organic acid blends improved piglet growth performance and health status, potentially by regulating intestinal redox homeostasis, immunity, and microflora.
format	article
author	Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun
author_facet	Xin-Dong Xiang Zhang-Chao Deng You-Wei Wang Hua Sun Li Wang Yan-Ming Han Yuan-Yuan Wu Jian-Gao Liu Lv-Hui Sun
author_sort	Xin-Dong Xiang
title	Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
title_short	Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
title_full	Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
title_fullStr	Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
title_full_unstemmed	Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets
title_sort	organic acids improve growth performance with potential regulation of redox homeostasis, immunity, and microflora in intestines of weaned piglets
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1def00f2188a49d1bc09237d632e68d4
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Organic Acids Improve Growth Performance with Potential Regulation of Redox Homeostasis, Immunity, and Microflora in Intestines of Weaned Piglets

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