Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed light on TRPM8 activation by menthol at the a...

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Autores principales: Lizhen Xu, Yalan Han, Xiaoying Chen, Aerziguli Aierken, Han Wen, Wenjun Zheng, Hongkun Wang, Xiancui Lu, Zhenye Zhao, Cheng Ma, Ping Liang, Wei Yang, Shilong Yang, Fan Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1df0403b22474bf6aa28de551bc14144
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spelling oai:doaj.org-article:1df0403b22474bf6aa28de551bc141442021-12-02T16:25:00ZMolecular mechanisms underlying menthol binding and activation of TRPM8 ion channel10.1038/s41467-020-17582-x2041-1723https://doaj.org/article/1df0403b22474bf6aa28de551bc141442020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17582-xhttps://doaj.org/toc/2041-1723Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed light on TRPM8 activation by menthol at the atomic level.Lizhen XuYalan HanXiaoying ChenAerziguli AierkenHan WenWenjun ZhengHongkun WangXiancui LuZhenye ZhaoCheng MaPing LiangWei YangShilong YangFan YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lizhen Xu
Yalan Han
Xiaoying Chen
Aerziguli Aierken
Han Wen
Wenjun Zheng
Hongkun Wang
Xiancui Lu
Zhenye Zhao
Cheng Ma
Ping Liang
Wei Yang
Shilong Yang
Fan Yang
Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
description Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed light on TRPM8 activation by menthol at the atomic level.
format article
author Lizhen Xu
Yalan Han
Xiaoying Chen
Aerziguli Aierken
Han Wen
Wenjun Zheng
Hongkun Wang
Xiancui Lu
Zhenye Zhao
Cheng Ma
Ping Liang
Wei Yang
Shilong Yang
Fan Yang
author_facet Lizhen Xu
Yalan Han
Xiaoying Chen
Aerziguli Aierken
Han Wen
Wenjun Zheng
Hongkun Wang
Xiancui Lu
Zhenye Zhao
Cheng Ma
Ping Liang
Wei Yang
Shilong Yang
Fan Yang
author_sort Lizhen Xu
title Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
title_short Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
title_full Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
title_fullStr Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
title_full_unstemmed Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
title_sort molecular mechanisms underlying menthol binding and activation of trpm8 ion channel
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1df0403b22474bf6aa28de551bc14144
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