Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Menthol in mints elicits a coolness sensation by selective activation of TRPM8 ion channel. Here authors dock menthol to TRPM8 and systematically validate their menthol binding models with thermodynamic mutant cycle analysis in functional tests, and shed light on TRPM8 activation by menthol at the a...

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Autores principales: Lizhen Xu, Yalan Han, Xiaoying Chen, Aerziguli Aierken, Han Wen, Wenjun Zheng, Hongkun Wang, Xiancui Lu, Zhenye Zhao, Cheng Ma, Ping Liang, Wei Yang, Shilong Yang, Fan Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1df0403b22474bf6aa28de551bc14144
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https://doaj.org/article/1df0403b22474bf6aa28de551bc14144

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