Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival

Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular processes. In addition to their role in maintaining bioenergetic homeostasis, changes in mitochondrial metabolism, permeabi...

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Autores principales:	Brittney Joy-Anne Foo, Jie Qing Eu, Jayshree L. Hirpara, Shazib Pervaiz
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/1df1168a281c4143a7923998f495dd76
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spelling	oai:doaj.org-article:1df1168a281c4143a7923998f495dd762021-11-15T01:18:59ZInterplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival1942-099410.1155/2021/1341604https://doaj.org/article/1df1168a281c4143a7923998f495dd762021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1341604https://doaj.org/toc/1942-0994Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular processes. In addition to their role in maintaining bioenergetic homeostasis, changes in mitochondrial metabolism, permeability, and morphology are critical in cell fate decisions and determination. Notably, mitochondrial respiration coupled with the passage of electrons through the electron transport chain (ETC) set up a potential source of reactive oxygen species (ROS). While low to moderate increase in intracellular ROS serves as secondary messenger, an overwhelming increase as a result of either increased production and/or deficient antioxidant defenses is detrimental to biomolecules, cells, and tissues. Since ROS and mitochondria both regulate cell fate, attention has been drawn to their involvement in the various processes of carcinogenesis. To that end, the link between a prooxidant milieu and cell survival and proliferation as well as a switch to mitochondrial OXPHOS associated with recalcitrant cancers provide testimony for the remarkable metabolic plasticity as an important hallmark of cancers. In this review, the regulation of cell redox status by mitochondrial metabolism and its implications for cancer cell fate will be discussed followed by the significance of mitochondria-targeted therapies for cancer.Brittney Joy-Anne FooJie Qing EuJayshree L. HirparaShazib PervaizHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Brittney Joy-Anne Foo Jie Qing Eu Jayshree L. Hirpara Shazib Pervaiz Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
description	Mitochondria are the main powerhouse of the cell, generating ATP through the tricarboxylic acid cycle (TCA) and oxidative phosphorylation (OXPHOS), which drives myriad cellular processes. In addition to their role in maintaining bioenergetic homeostasis, changes in mitochondrial metabolism, permeability, and morphology are critical in cell fate decisions and determination. Notably, mitochondrial respiration coupled with the passage of electrons through the electron transport chain (ETC) set up a potential source of reactive oxygen species (ROS). While low to moderate increase in intracellular ROS serves as secondary messenger, an overwhelming increase as a result of either increased production and/or deficient antioxidant defenses is detrimental to biomolecules, cells, and tissues. Since ROS and mitochondria both regulate cell fate, attention has been drawn to their involvement in the various processes of carcinogenesis. To that end, the link between a prooxidant milieu and cell survival and proliferation as well as a switch to mitochondrial OXPHOS associated with recalcitrant cancers provide testimony for the remarkable metabolic plasticity as an important hallmark of cancers. In this review, the regulation of cell redox status by mitochondrial metabolism and its implications for cancer cell fate will be discussed followed by the significance of mitochondria-targeted therapies for cancer.
format	article
author	Brittney Joy-Anne Foo Jie Qing Eu Jayshree L. Hirpara Shazib Pervaiz
author_facet	Brittney Joy-Anne Foo Jie Qing Eu Jayshree L. Hirpara Shazib Pervaiz
author_sort	Brittney Joy-Anne Foo
title	Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
title_short	Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
title_full	Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
title_fullStr	Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
title_full_unstemmed	Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival
title_sort	interplay between mitochondrial metabolism and cellular redox state dictates cancer cell survival
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/1df1168a281c4143a7923998f495dd76
work_keys_str_mv	AT brittneyjoyannefoo interplaybetweenmitochondrialmetabolismandcellularredoxstatedictatescancercellsurvival AT jieqingeu interplaybetweenmitochondrialmetabolismandcellularredoxstatedictatescancercellsurvival AT jayshreelhirpara interplaybetweenmitochondrialmetabolismandcellularredoxstatedictatescancercellsurvival AT shazibpervaiz interplaybetweenmitochondrialmetabolismandcellularredoxstatedictatescancercellsurvival
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Interplay between Mitochondrial Metabolism and Cellular Redox State Dictates Cancer Cell Survival

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