A constricted opening in Kir channels does not impede potassium conduction
The transition between conducting and non-conducting states of K+ channels has been explained by conformational changes at the intracellular entrance to the conduction pathway. Here authors demonstrate that control over K+ currents in Kir channels is not explained by the canonical pore-gating model,...
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| Lenguaje: | EN |
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/1df537b978c34d8f93ba5ec69176a90f |
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oai:doaj.org-article:1df537b978c34d8f93ba5ec69176a90f2021-12-02T17:39:52ZA constricted opening in Kir channels does not impede potassium conduction10.1038/s41467-020-16842-02041-1723https://doaj.org/article/1df537b978c34d8f93ba5ec69176a90f2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16842-0https://doaj.org/toc/2041-1723The transition between conducting and non-conducting states of K+ channels has been explained by conformational changes at the intracellular entrance to the conduction pathway. Here authors demonstrate that control over K+ currents in Kir channels is not explained by the canonical pore-gating model, as conduction is not impaired by a constricted inner helix bundle.Katrina A. BlackSitong HeRuitao JinDavid M. MillerJani R. BollaOliver B. ClarkePaul JohnsonMonique WindleyChristopher J. BurnsAdam P. HillDerek LaverCarol V. RobinsonBrian J. SmithJacqueline M. GulbisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Katrina A. Black Sitong He Ruitao Jin David M. Miller Jani R. Bolla Oliver B. Clarke Paul Johnson Monique Windley Christopher J. Burns Adam P. Hill Derek Laver Carol V. Robinson Brian J. Smith Jacqueline M. Gulbis A constricted opening in Kir channels does not impede potassium conduction |
| description |
The transition between conducting and non-conducting states of K+ channels has been explained by conformational changes at the intracellular entrance to the conduction pathway. Here authors demonstrate that control over K+ currents in Kir channels is not explained by the canonical pore-gating model, as conduction is not impaired by a constricted inner helix bundle. |
| format |
article |
| author |
Katrina A. Black Sitong He Ruitao Jin David M. Miller Jani R. Bolla Oliver B. Clarke Paul Johnson Monique Windley Christopher J. Burns Adam P. Hill Derek Laver Carol V. Robinson Brian J. Smith Jacqueline M. Gulbis |
| author_facet |
Katrina A. Black Sitong He Ruitao Jin David M. Miller Jani R. Bolla Oliver B. Clarke Paul Johnson Monique Windley Christopher J. Burns Adam P. Hill Derek Laver Carol V. Robinson Brian J. Smith Jacqueline M. Gulbis |
| author_sort |
Katrina A. Black |
| title |
A constricted opening in Kir channels does not impede potassium conduction |
| title_short |
A constricted opening in Kir channels does not impede potassium conduction |
| title_full |
A constricted opening in Kir channels does not impede potassium conduction |
| title_fullStr |
A constricted opening in Kir channels does not impede potassium conduction |
| title_full_unstemmed |
A constricted opening in Kir channels does not impede potassium conduction |
| title_sort |
constricted opening in kir channels does not impede potassium conduction |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1df537b978c34d8f93ba5ec69176a90f |
| work_keys_str_mv |
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