Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

Pasi Vottonen,1 Kai Kaarniranta,1,2 Ari P&auml;&auml;kk&ouml;nen,3 Ina M Tarkka41Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland; 2Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; 3Department...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vottonen P, Kaarniranta K, P&auml;&auml;kk&ouml;nen A, Tarkka IM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1df606d0fac94a818d87d192228ba31f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1df606d0fac94a818d87d192228ba31f
record_format	dspace
spelling	oai:doaj.org-article:1df606d0fac94a818d87d192228ba31f2021-12-02T00:56:43ZChanges in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration1177-54671177-5483https://doaj.org/article/1df606d0fac94a818d87d192228ba31f2013-02-01T00:00:00Zhttp://www.dovepress.com/changes-in-neurophysiologic-markers-of-visual-processing-following-ben-a12310https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Pasi Vottonen,1 Kai Kaarniranta,1,2 Ari P&auml;&auml;kk&ouml;nen,3 Ina M Tarkka41Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland; 2Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; 3Department of Clinical Neurophysiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; 4Department of Health Sciences, University of Jyv&auml;skyl&auml;, Jyv&auml;skyl&auml;, FinlandPurpose: Antivascular endothelial growth factor (VEGF) agents have been shown to improve visual acuity and prevent vision loss in exudative age-related macular degeneration. As the vision improves relatively quickly in response to intravitreal injections, we wanted to know whether this improvement is reflected in electrophysiological markers of visual cortical processing.Patients and methods: Our interventional case series included six elderly patients who underwent injection treatment to the affected eye. Their visual acuity, tomographic images of retinal thickness, and visual evoked potentials (VEP) were assessed before treatment and six weeks after the last injection.Results: All patients showed improved visual acuity and reduced retinal fluid after the treatment. All but one patient showed increased VEP P100 component amplitudes and/or shortened latencies in the treated eye. These VEP changes were consistent with improved vision while the untreated eyes showed no changes.Conclusions: Our results indicate that antivascular endothelial growth factor injections improved visual function of the treated eyes both in the level of the retina and in the level of visual cortical processing.Keywords: age-related eye diseases, exudative age-related macular degeneration, visual evoked potentials, scalp-recorded EEG, visual acuityVottonen PKaarniranta KP&auml;&auml;kk&ouml;nen ATarkka IMDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 437-442 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Vottonen P Kaarniranta K P&auml;&auml;kk&ouml;nen A Tarkka IM Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
description	Pasi Vottonen,1 Kai Kaarniranta,1,2 Ari P&auml;&auml;kk&ouml;nen,3 Ina M Tarkka41Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland; 2Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; 3Department of Clinical Neurophysiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; 4Department of Health Sciences, University of Jyv&auml;skyl&auml;, Jyv&auml;skyl&auml;, FinlandPurpose: Antivascular endothelial growth factor (VEGF) agents have been shown to improve visual acuity and prevent vision loss in exudative age-related macular degeneration. As the vision improves relatively quickly in response to intravitreal injections, we wanted to know whether this improvement is reflected in electrophysiological markers of visual cortical processing.Patients and methods: Our interventional case series included six elderly patients who underwent injection treatment to the affected eye. Their visual acuity, tomographic images of retinal thickness, and visual evoked potentials (VEP) were assessed before treatment and six weeks after the last injection.Results: All patients showed improved visual acuity and reduced retinal fluid after the treatment. All but one patient showed increased VEP P100 component amplitudes and/or shortened latencies in the treated eye. These VEP changes were consistent with improved vision while the untreated eyes showed no changes.Conclusions: Our results indicate that antivascular endothelial growth factor injections improved visual function of the treated eyes both in the level of the retina and in the level of visual cortical processing.Keywords: age-related eye diseases, exudative age-related macular degeneration, visual evoked potentials, scalp-recorded EEG, visual acuity
format	article
author	Vottonen P Kaarniranta K P&auml;&auml;kk&ouml;nen A Tarkka IM
author_facet	Vottonen P Kaarniranta K P&auml;&auml;kk&ouml;nen A Tarkka IM
author_sort	Vottonen P
title	Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
title_short	Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
title_full	Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
title_fullStr	Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
title_full_unstemmed	Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration
title_sort	changes in neurophysiologic markers of visual processing following beneficial anti-vegf treatment in macular degeneration
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/1df606d0fac94a818d87d192228ba31f
work_keys_str_mv	AT vottonenp changesinneurophysiologicmarkersofvisualprocessingfollowingbeneficialantivegftreatmentinmaculardegeneration AT kaarnirantak changesinneurophysiologicmarkersofvisualprocessingfollowingbeneficialantivegftreatmentinmaculardegeneration AT pampaumlampaumlkkampoumlnena changesinneurophysiologicmarkersofvisualprocessingfollowingbeneficialantivegftreatmentinmaculardegeneration AT tarkkaim changesinneurophysiologicmarkersofvisualprocessingfollowingbeneficialantivegftreatmentinmaculardegeneration
_version_	1718403368779513856

Changes in neurophysiologic markers of visual processing following beneficial anti-VEGF treatment in macular degeneration

Ejemplares similares