Intraoperative radiation therapy for breast cancer patients: current perspectives

Sunil W Dutta,1 Shayna L Showalter,2 Timothy N Showalter,1 Bruce Libby,1 Daniel M Trifiletti1 1Department of Radiation Oncology, 2Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA Abstract: Accelerated partial breast irradiatio...

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Autores principales:	Dutta SW, Showalter SL, Showalter TN, Libby B, Trifiletti DM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	breast cancer IORT radiation lumpectomy intraoperative Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1df73380cc244db7b4804fc6dde2b9e2
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spelling	oai:doaj.org-article:1df73380cc244db7b4804fc6dde2b9e22021-12-02T02:43:41ZIntraoperative radiation therapy for breast cancer patients: current perspectives1179-1314https://doaj.org/article/1df73380cc244db7b4804fc6dde2b9e22017-04-01T00:00:00Zhttps://www.dovepress.com/intraoperative-radiation-therapy-for-breast-cancer-patients-current-pe-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Sunil W Dutta,1 Shayna L Showalter,2 Timothy N Showalter,1 Bruce Libby,1 Daniel M Trifiletti1 1Department of Radiation Oncology, 2Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA Abstract: Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience. Keywords: IORT, lumpectomy, breast conservation, electron, photon, evidenceDutta SWShowalter SLShowalter TNLibby BTrifiletti DMDove Medical Pressarticlebreast cancerIORTradiationlumpectomyintraoperativeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 257-263 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer IORT radiation lumpectomy intraoperative Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer IORT radiation lumpectomy intraoperative Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dutta SW Showalter SL Showalter TN Libby B Trifiletti DM Intraoperative radiation therapy for breast cancer patients: current perspectives
description	Sunil W Dutta,1 Shayna L Showalter,2 Timothy N Showalter,1 Bruce Libby,1 Daniel M Trifiletti1 1Department of Radiation Oncology, 2Division of Surgical Oncology, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA Abstract: Accelerated partial breast irradiation (APBI) provides an attractive alternative to whole breast irradiation (WBI) through normal tissue radiation exposure and reduced treatment duration. Intraoperative radiation therapy (IORT) is a form of APBI with the shortest time interval, as it delivers the entirety of a planned radiation course at the time of breast surgery. However, faster is not always better, and IORT has been met with healthy skepticism. Patients treated with IORT have an increased compliance and overall satisfaction when compared to patients treated with WBI. However, early randomized trial results demonstrated an increased rate of recurrence after IORT, slowing its widespread adoption. Despite these controversies, IORT utilization is increasing nationally and several novel developments are aimed at continuing to minimize the risk of recurrence and treatment-related toxicity while maximizing the patient experience. Keywords: IORT, lumpectomy, breast conservation, electron, photon, evidence
format	article
author	Dutta SW Showalter SL Showalter TN Libby B Trifiletti DM
author_facet	Dutta SW Showalter SL Showalter TN Libby B Trifiletti DM
author_sort	Dutta SW
title	Intraoperative radiation therapy for breast cancer patients: current perspectives
title_short	Intraoperative radiation therapy for breast cancer patients: current perspectives
title_full	Intraoperative radiation therapy for breast cancer patients: current perspectives
title_fullStr	Intraoperative radiation therapy for breast cancer patients: current perspectives
title_full_unstemmed	Intraoperative radiation therapy for breast cancer patients: current perspectives
title_sort	intraoperative radiation therapy for breast cancer patients: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1df73380cc244db7b4804fc6dde2b9e2
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Intraoperative radiation therapy for breast cancer patients: current perspectives

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