Autophagy is inhibited by ubiquitin ligase activity in the nervous system

Despite growing interest in the role of autophagy in neurons, it remains unclear how this process is regulated, in particular, how autophagy is spatially restricted in subcellular compartments in neurons. In this study, the authors use an unbiased proteomic approach to show that the autophagy initia...

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Autores principales:	Oliver Crawley, Karla J. Opperman, Muriel Desbois, Isabel Adrados, Melissa A. Borgen, Andrew C. Giles, Derek R. Duckett, Brock Grill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1df888c78b5d4bdb956fe12ca5196ab5
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spelling	oai:doaj.org-article:1df888c78b5d4bdb956fe12ca5196ab52021-12-02T16:57:43ZAutophagy is inhibited by ubiquitin ligase activity in the nervous system10.1038/s41467-019-12804-32041-1723https://doaj.org/article/1df888c78b5d4bdb956fe12ca5196ab52019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12804-3https://doaj.org/toc/2041-1723Despite growing interest in the role of autophagy in neurons, it remains unclear how this process is regulated, in particular, how autophagy is spatially restricted in subcellular compartments in neurons. In this study, the authors use an unbiased proteomic approach to show that the autophagy initiating kinase UNC-51/ULK and autophagosome formation are inhibited by the ubiquitin ligase RPM-1, and demonstrate that this interaction is within specific axonal compartments.Oliver CrawleyKarla J. OppermanMuriel DesboisIsabel AdradosMelissa A. BorgenAndrew C. GilesDerek R. DuckettBrock GrillNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oliver Crawley Karla J. Opperman Muriel Desbois Isabel Adrados Melissa A. Borgen Andrew C. Giles Derek R. Duckett Brock Grill Autophagy is inhibited by ubiquitin ligase activity in the nervous system
description	Despite growing interest in the role of autophagy in neurons, it remains unclear how this process is regulated, in particular, how autophagy is spatially restricted in subcellular compartments in neurons. In this study, the authors use an unbiased proteomic approach to show that the autophagy initiating kinase UNC-51/ULK and autophagosome formation are inhibited by the ubiquitin ligase RPM-1, and demonstrate that this interaction is within specific axonal compartments.
format	article
author	Oliver Crawley Karla J. Opperman Muriel Desbois Isabel Adrados Melissa A. Borgen Andrew C. Giles Derek R. Duckett Brock Grill
author_facet	Oliver Crawley Karla J. Opperman Muriel Desbois Isabel Adrados Melissa A. Borgen Andrew C. Giles Derek R. Duckett Brock Grill
author_sort	Oliver Crawley
title	Autophagy is inhibited by ubiquitin ligase activity in the nervous system
title_short	Autophagy is inhibited by ubiquitin ligase activity in the nervous system
title_full	Autophagy is inhibited by ubiquitin ligase activity in the nervous system
title_fullStr	Autophagy is inhibited by ubiquitin ligase activity in the nervous system
title_full_unstemmed	Autophagy is inhibited by ubiquitin ligase activity in the nervous system
title_sort	autophagy is inhibited by ubiquitin ligase activity in the nervous system
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1df888c78b5d4bdb956fe12ca5196ab5
work_keys_str_mv	AT olivercrawley autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT karlajopperman autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT murieldesbois autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT isabeladrados autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT melissaaborgen autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT andrewcgiles autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT derekrduckett autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem AT brockgrill autophagyisinhibitedbyubiquitinligaseactivityinthenervoussystem
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Autophagy is inhibited by ubiquitin ligase activity in the nervous system

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