SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17...

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Autores principales:	Amir Kumar Singh, Prashant Khare, Abeer Obaid, Kevin P. Conlon, Venkatesha Basrur, Ronald A. DePinho, K. Venuprasad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1df8e582f787431da6877b852dc40340
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spelling	oai:doaj.org-article:1df8e582f787431da6877b852dc403402021-12-02T16:49:55ZSUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC210.1038/s41467-018-06924-52041-1723https://doaj.org/article/1df8e582f787431da6877b852dc403402018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06924-5https://doaj.org/toc/2041-1723Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17 production in Th17 cells.Amir Kumar SinghPrashant KhareAbeer ObaidKevin P. ConlonVenkatesha BasrurRonald A. DePinhoK. VenuprasadNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
description	Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17 production in Th17 cells.
format	article
author	Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad
author_facet	Amir Kumar Singh Prashant Khare Abeer Obaid Kevin P. Conlon Venkatesha Basrur Ronald A. DePinho K. Venuprasad
author_sort	Amir Kumar Singh
title	SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
title_short	SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
title_full	SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
title_fullStr	SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
title_full_unstemmed	SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
title_sort	sumoylation of ror-γt inhibits il-17 expression and inflammation via hdac2
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1df8e582f787431da6877b852dc40340
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SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

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