SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2

Interleukin-17 (IL-17)-secreting CD4 T cells (Th17) are induced by the master transcription factor RORγt, and are important for anti-fungal immunity and inflammatory responses. Here the authors show that Ubc9-mediated SUMOylation of RORγt induces HDAC2 binding to IL-17 promoter for suppressing IL-17...

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Autores principales: Amir Kumar Singh, Prashant Khare, Abeer Obaid, Kevin P. Conlon, Venkatesha Basrur, Ronald A. DePinho, K. Venuprasad
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/1df8e582f787431da6877b852dc40340
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